Role of inflammasomes and neuroinflammation in epilepsy
A Hollis, JR Lukens - Immunological Reviews, 2024 - Wiley Online Library
Epilepsy is a brain disorder characterized by recurrent seizures, which are brief episodes of
abnormal electrical activity in the brain and involuntary movement that can lead to physical …
abnormal electrical activity in the brain and involuntary movement that can lead to physical …
Liquid–liquid phase separation in innate immunity
D Liu, J Yang, IM Cristea - Trends in Immunology, 2024 - cell.com
Intrinsic and innate immune responses are essential lines of defense in the body's constant
surveillance of pathogens. The discovery of liquid–liquid phase separation (LLPS) as a key …
surveillance of pathogens. The discovery of liquid–liquid phase separation (LLPS) as a key …
The cytoplasmic sensor, the AIM2 inflammasome: A precise therapeutic target in vascular and metabolic diseases
J Lin, J Wang, J Fang, M Li, S Xu… - British Journal of …, 2024 - Wiley Online Library
Cardio‐cerebrovascular diseases encompass pathological changes in the heart, brain and
vascular system, which pose a great threat to health and well‐being worldwide. Moreover …
vascular system, which pose a great threat to health and well‐being worldwide. Moreover …
The roles of AIM2 in neurodegenerative diseases: insights and therapeutic implications
K Yang, X Wang, H Pan, X Wang, Y Hu, Y Yao… - Frontiers in …, 2024 - frontiersin.org
AIM2, a cytosolic innate immune receptor, has the capability to recognize double-stranded
DNA (dsDNA). This paper delineates the structural features of AIM2 and its mechanisms of …
DNA (dsDNA). This paper delineates the structural features of AIM2 and its mechanisms of …
Strategies of bacterial detection by inflammasomes
JB Jastrab, JC Kagan - Cell Chemical Biology, 2024 - cell.com
Mammalian innate immunity is regulated by pattern-recognition receptors (PRRs) and guard
proteins, which use distinct strategies to detect infections. PRRs detect bacterial molecules …
proteins, which use distinct strategies to detect infections. PRRs detect bacterial molecules …
Mitochondrial dysfunction, a weakest link of network of aging, relation to innate intramitochondrial immunity of DNA recognition receptors
DX Tan - Mitochondrion, 2024 - Elsevier
Aging probably is the most complexed process in biology. It is manifested by a variety of
hallmarks. These hallmarks weave a network of aging; however, each hallmark is not …
hallmarks. These hallmarks weave a network of aging; however, each hallmark is not …
The Role of the AIM2 Gene in Obesity-Related Glucose and Lipid Metabolic Disorders: A Recent Update
Y Zhang, X Xuan, D Ye, D Liu, Y Song… - … Syndrome and Obesity, 2024 - Taylor & Francis
Abstract Absent in melanoma 2 (AIM2) is a protein encoded by the AIM2 gene located on
human chromosomes, AIM2 can recognize and bind to double stranded DNA (dsDNA) …
human chromosomes, AIM2 can recognize and bind to double stranded DNA (dsDNA) …
The atypical filament assembly underpins the inflammasome-independent functions of IFI16.
Inflammasomes trigger cell death upon sensing various intracellular maladies. These supra-
structures relay upstream signals by sequentially assembling architecturally congruent …
structures relay upstream signals by sequentially assembling architecturally congruent …
Dimerization-dependent gel-like condensation with dsDNA underpins the activation of human cGAS
Cyclic G/AMP Synthase (cGAS) initiates inflammatory responses against pathogenic double-
stranded (ds) DNA. Although it is well established that cGAS forms phase-separated …
stranded (ds) DNA. Although it is well established that cGAS forms phase-separated …