Rotavirus: Genetics, pathogenesis and vaccine advances
Since its discovery 40 years ago, rotavirus (RV) is considered to be a major cause of infant
and childhood morbidity and mortality particularly in developing countries. Nearly every …
and childhood morbidity and mortality particularly in developing countries. Nearly every …
Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses
RNA viruses induce the formation of subcellular organelles that provide microenvironments
conducive to their replication. Here we show that replication factories of rotaviruses …
conducive to their replication. Here we show that replication factories of rotaviruses …
VP4-and VP7-specific antibodies mediate heterotypic immunity to rotavirus in humans
Human rotaviruses (RVs) are the leading cause of severe diarrhea in young children
worldwide. The molecular mechanisms underlying the rapid induction of heterotypic …
worldwide. The molecular mechanisms underlying the rapid induction of heterotypic …
Reovirus σNS and μNS proteins remodel the endoplasmic reticulum to build replication neo-organelles
R Tenorio, I Fernández de Castro, JJ Knowlton… - MBio, 2018 - Am Soc Microbiol
Like most viruses that replicate in the cytoplasm, mammalian reoviruses assemble
membranous neo-organelles called inclusions that serve as sites of viral genome replication …
membranous neo-organelles called inclusions that serve as sites of viral genome replication …
Rotavirus NSP2: A Master Orchestrator of Early Viral Particle Assembly
SL Nichols, C Haller, A Borodavka, SM Esstman - Viruses, 2024 - mdpi.com
Rotaviruses (RVs) are 11-segmented, double-stranded (ds) RNA viruses and important
causes of acute gastroenteritis in humans and other animal species. Early RV particle …
causes of acute gastroenteritis in humans and other animal species. Early RV particle …
Rotavirus viroplasm fusion and perinuclear localization are dynamic processes requiring stabilized microtubules
C Eichwald, F Arnoldi, AS Laimbacher, EM Schraner… - 2012 - journals.plos.org
Rotavirus viroplasms are cytosolic, electron-dense inclusions corresponding to the viral
machinery of replication responsible for viral template transcription, dsRNA genome …
machinery of replication responsible for viral template transcription, dsRNA genome …
The recruitment of TRiC chaperonin in rotavirus viroplasms correlates with virus replication
Rotavirus (RV) replication takes place in the viroplasms, cytosolic inclusions that allow the
synthesis of virus genome segments and their encapsidation in the core shell, followed by …
synthesis of virus genome segments and their encapsidation in the core shell, followed by …
Gangliosides have a functional role during rotavirus cell entry
Cell entry of rotaviruses is a complex process, which involves sequential interactions with
several cell surface molecules. Among the molecules implicated are gangliosides …
several cell surface molecules. Among the molecules implicated are gangliosides …
Characterization of viroplasm-like structures by co-expression of NSP5 and NSP2 across rotavirus species A to J
Rotaviruses (RVs) are classified into nine species, A–D and F–J, with species A being the
most studied. In rotavirus of species A (RVA), replication occurs in viroplasms, which are …
most studied. In rotavirus of species A (RVA), replication occurs in viroplasms, which are …
Replication of the rotavirus genome requires an active ubiquitin-proteasome system
Here we show that the ubiquitin-proteasome system is required for the efficient replication of
rotavirus RRV in MA104 cells. The proteasome inhibitor MG132 decreased the yield of …
rotavirus RRV in MA104 cells. The proteasome inhibitor MG132 decreased the yield of …