Rhein (4, 5‐dihydroxyanthraquinone‐2‐carboxylic acid) is a lipophilic anthraquinone
extensively found in medicinal herbs, such as Rheum palmatum L., Cassia tora L …

According to the World Health Organization (WHO), cancer is the second-highest cause of
mortality in the world, and it kills nearly 9.6 million people annually. Besides the fatality of the …

Cancer cells are characterized by self-sufficiency in the absence of growth signals, their
ability to evade apoptosis, resistance to anti-growth signals, sustained angiogenesis …

Cancer cells produce high levels of reactive oxygen species (ROS) that lead to a state of
increased basal oxidative stress. Since this state of oxidative stress makes cancer cells …

Rhein is a major medicinal ingredient isolated from several traditional Chinese medicines,
including Rheum palmatum L., Aloe barbadensis Miller, Cassia angustifolia Vahl., and …

Anthraquinone compounds have been shown to induce apoptosis in different cancer cell
types. Effects of chrysophanol, an anthraquinone compound, on cancer cell death have not …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease which affects about
0.5–1% of people with symptoms that significantly impact a sufferer's lifestyle. The cells …

Background Liver cancer is one of common types of cancer with poor prognosis and limited
therapies. Heat shock proteins (HSP) are molecular chaperones that have important roles in …

Malignant gliomas are common primary tumors of the central nervous system. The prognosis
of patients with malignant glioma is poor in spite of current intensive therapy and thus novel …

Cordycepin is known to have many pharmacological effects such as anti-tumorigenic, anti-
inflammatory and anti-angiogenic activity. However, cordycepin induced apoptosis through …