Patterning the vertebrate neuraxis

A Lumsden, R Krumlauf - Science, 1996 - science.org
Neuraxial patterning is a continuous process that extends over a protracted period of
development. During gastrulation a crude anteroposterior pattern, detectable by molecular …

Segmentation and patterning of the vertebrate hindbrain

R Krumlauf, DG Wilkinson - Development, 2021 - journals.biologists.com
During early development, the hindbrain is sub-divided into rhombomeres that underlie the
organisation of neurons and adjacent craniofacial tissues. A gene regulatory network of …

A single cell transcriptome atlas of the developing zebrafish hindbrain

M Tambalo, R Mitter, DG Wilkinson - Development, 2020 - journals.biologists.com
Segmentation of the vertebrate hindbrain leads to the formation of rhombomeres, each with
a distinct anteroposterior identity. Specialised boundary cells form at segment borders that …

A Hox gene regulatory network for hindbrain segmentation

HJ Parker, R Krumlauf - Current topics in developmental biology, 2020 - Elsevier
In vertebrates, the hindbrain serves as a highly conserved complex coordination center for
regulating many fundamental activities of the central nervous system, such as respiratory …

Forced to communicate: Integration of mechanical and biochemical signaling in morphogenesis

A Kindberg, JK Hu, JO Bush - Current opinion in cell biology, 2020 - Elsevier
Morphogenesis is a physical process that requires the generation of mechanical forces to
achieve dynamic changes in cell position, tissue shape, and size as well as biochemical …

Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups

MJ Lobón-Iglesias, M Andrianteranagna… - Nature …, 2023 - nature.com
Atypical teratoid rhabdoid tumors (ATRT) are divided into MYC, TYR and SHH subgroups,
suggesting diverse lineages of origin. Here, we investigate the imaging of human ATRT at …

Hindbrain induction and patterning during early vertebrate development

D Frank, D Sela-Donenfeld - Cellular and molecular life sciences, 2019 - Springer
The hindbrain is a key relay hub of the central nervous system (CNS), linking the bilaterally
symmetric half-sides of lower and upper CNS centers via an extensive network of neural …

Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation

A Voltes, CF Hevia, C Engel-Pizcueta… - …, 2019 - journals.biologists.com
Cells perceive their microenvironment through chemical and physical cues. However, how
the mechanical signals are interpreted during embryonic tissue deformation to result in …

[HTML][HTML] The neurogenic fate of the hindbrain boundaries relies on Notch3-dependent asymmetric cell divisions

CF Hevia, C Engel-Pizcueta, F Udina, C Pujades - Cell Reports, 2022 - cell.com
Elucidating the cellular and molecular mechanisms that regulate the balance between
progenitor cell proliferation and neuronal differentiation in the construction of the embryonic …

The role of PHOX2B‐derived astrocytes in chemosensory control of breathing and sleep homeostasis

CM Czeisler, TM Silva, SR Fair, J Liu… - The Journal of …, 2019 - Wiley Online Library
Key points The embryonic PHOX2B‐progenitor domain generates neuronal and glial cells
which together are involved in chemosensory control of breathing and sleep homeostasis …