Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a
critical role in numerous human physiological and pathological conditions. Thus …

Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into
peptides. There are many distinct forms of proteasomes that differ in catalytically active …

To date, the endogenous ligands described for cannabinoid receptors have been derived
from membrane lipids. To identify a peptide ligand for CB1 cannabinoid receptors, we used …

Electrospray ionization mass spectrometry (ESI‐MS) is found to gently and efficiently transfer
small to large as well as singly to multiply charged [X+] n [A−] m supramolecules of …

The degradation of cellular proteins by proteasomes generates peptides 2–24 residues
long, which are hydrolyzed rapidly to amino acids. To define the final steps in this pathway …

We have found various bioactive peptides derived from animal and plant proteins, which
interact with receptors for endogenous bioactive peptides such as opioids, neurotensin …

Hemoglobin gene expression in non-erythroid cells has been previously reported in
activated macrophages from adult mice and lens cells, and recent studies indicate that …

Peptides are known to play many important physiological roles in signaling. A large number
of peptides have been detected in mouse brain extracts using mass spectrometry-based …

Two genes encoding the enzymes 1-deoxy-d-xylulose-5-phosphate synthase and 1-deoxy-d-
xylulose-5-phosphate reductoisomerase have been recently identified, suggesting that …

Most bioactive peptides are generated by proteolytic cleavage of large precursor proteins
followed by storage in secretory vesicles from where they are released upon cell stimulation …