Histone lysine methylation is a post-translational modification that plays a key role in the
epigenetic regulation of a broad spectrum of biological processes. Moreover, the …

Histone methylation reader domains are protein modules that recognize specific histone
methylation marks, such as methylated or unmethylated lysine or arginine residues on …

Epithelioid sarcoma (EpS) is an ultra-rare malignant soft-tissue cancer mostly affecting
adolescents and young adults. EpS often exhibits an unfavorable clinical course with fatal …

Introduction Despite extensive research undertaken in the past 20–30 years, the treatment
for soft tissue sarcoma (STS) has remained largely the same, with anthracycline-based …

Purpose: Ultra-rare sarcomas (URS) comprise a group of orphan diseases with an incidence
of≤ 1/1,000,000 people per year. We aimed to assess clinically actionable genomic …

9.1 Background Histone acetylation is a dynamic process that regulates transcription. In
general, acetylation of positively charged lysine residues on histone tails changes their …

Histone lysine methylation is a post-translational modification that plays a key role in the
epigenetic regulation of a broad spectrum of biological processes. Moreover, the …