Studies of the choroid plexus lag behind those of the more widely known blood-brain barrier,
despite a much longer history. This review has two overall aims. The first is to outline long …

Advancement in biotechnology provided a notable expansion of peptide and protein
therapeutics, used as antigens, vaccines, hormones. It has a prodigious potential to treat a …

Choroid plexus (ChP) epithelial cells are crucial for the function of the blood-cerebrospinal
fluid barrier (BCSFB) in the developing and mature brain. The ChP is considered the primary …

In recent years, unique physicochemical properties of amphiphilic block copolymers have
been utilized to design the polymeric micelles for brain-specific delivery of drugs, proteins …

The blood–brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) represent
two complex structures protecting the central nervous system (CNS) against potentially …

The brain is protected against invading organisms and other unwanted substances by tightly
regulated barriers. However, these central nervous system (CNS) barriers impede the …

The treatment of central nervous system (CNS) pathologies is severely hampered by the
presence of tightly regulated CNS barriers that restrict drug delivery to the brain. An …

Pathogen-specific immunity evolves in the context of the infected tissue. However, current
immune correlates analyses and vaccine efficacy metrics are based on immune functions …

Here, we have investigated the effect of size of protein therapeutics on brain
pharmacokinetics (PK) following systemic administration in rats. All tested proteins were …

The pharmaceutical research sector has been facing the challenge of neurotherapeutics
development and its inherited high-risk and high-failure-rate nature for decades. This hurdle …