The endocannabinoids are lipid-derived messengers that play a diversity of regulatory roles
in mammalian physiology. Dysfunctions in their activity have been implicated in various …

Background The “classic” endocannabinoid (eCB) system includes the cannabinoid
receptors CB1 and CB2, the eCB ligands anandamide (AEA) and 2-arachidonoylglycerol (2 …

Fatty acid amide hydrolase (FAAH) is an important enzyme creditworthy of hydrolyzing
endocannabinoids and related-amidated signalling lipids, discovery of which has pioneered …

Polypharmacology breaks up the classical paradigm of “one-drug, one target, one disease”
electing multitarget compounds as potential therapeutic tools suitable for the treatment of …

Evidence suggests that some nonsteroidal anti-inflammatory drugs (NSAIDs) possess
antibacterial properties with an unknown mechanism. We describe the in vitro antibacterial …

Alzheimer's disease (AD) is a widespread multifactorial aging-related pathology, which
includes cholinergic deficit among its main causes. Following a multi-target design strategy …

Conspectus The regulatory chemical mechanisms of lipid trafficking and degradation are
involved in many pathophysiological processes, being implicated in severe pain …

Pharmaceuticals are important in medical care because they improve life quality and extend
life expectancy, particularly in chronic diseases. Pravadoline is a non-steroidal anti …

Chronic pain determines a substantial burden on individuals, employers, healthcare
systems, and society. Most of the affected patients report dissatisfaction with currently …

In pharmaceutical science and drug design the versatility of the pyrrolidine scaffold relating
to spatial arrangement, synthetic accessibility and pharmacological profile is a largely …