Lymph nodes (LNs) are strategically positioned at dedicated sites throughout the body to
facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs …

Worldwide, each year over 30,000 patients undergo an allogeneic hema-topoietic stem cell
transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency …

Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

Acute graft-versus-host disease (GVHD) is a major life-threatening complication after
allogeneic hematopoietic cell transplantation (allo-HCT). The classical target organs of …

Alloreactive and autoimmune responses after allogeneic hematopoietic cell transplantation
can occur in nonclassical chronic graft-versus-host disease (chronic GVHD) tissues and …

Lymph nodes (LNs) aid the interaction between lymphocytes and antigen-presenting cells,
resulting in adequate and prolonged adaptive immune responses. LN stromal cells (LNSCs) …

Patients with chronic graft-versus-host disease (cGVHD) have increased B cell–activating
factor (BAFF) levels, but whether BAFF promotes disease after allogeneic bone marrow …

Preventing chronic graft-versus-host disease (GVHD) remains challenging because the
unique cellular and molecular pathways that incite chronic GVHD are poorly understood …

Regenerative failure at barrier surfaces and maladaptive repair leading to fibrosis are
hallmarks of graft-versus-host disease (GVHD). Although immunosuppressive treatment can …

As a result of impressive increases in our knowledge of rodent and human immunology, the
understanding of the pathophysiologic mechanisms underlying graft-versus-host disease …