Defining the extracellular matrix using proteomics

A Byron, JD Humphries… - International journal of …, 2013 - Wiley Online Library
The cell microenvironment has a profound influence on the behaviour, growth and survival
of cells. The extracellular matrix (ECM) provides not only mechanical and structural support …

[HTML][HTML] The kidney matrisome in health, aging, and disease

F Lausecker, R Lennon, MJ Randles - Kidney International, 2022 - Elsevier
Dysregulated extracellular matrix is the hallmark of fibrosis, and it has a profound impact on
kidney function in disease. Furthermore, perturbation of matrix homeostasis is a feature of …

Global analysis reveals the complexity of the human glomerular extracellular matrix

R Lennon, A Byron, JD Humphries… - Journal of the …, 2014 - journals.lww.com
The glomerulus contains unique cellular and extracellular matrix (ECM) components, which
are required for intact barrier function. Studies of the cellular components have helped to …

Global remodelling of cellular microenvironment due to loss of collagen VII

V Küttner, C Mack, KTG Rigbolt, JS Kern… - Molecular systems …, 2013 - embopress.org
The mammalian cellular microenvironment is shaped by soluble factors and structural
components, the extracellular matrix, providing physical support, regulating adhesion and …

Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver

ST Rashid, JD Humphries, A Byron… - Journal of proteome …, 2012 - ACS Publications
Activation of hepatic stellate cells (HSCs) and subsequent uncontrolled accumulation of
altered extracellular matrix (ECM) underpin liver fibrosis, a wound healing response to …

Long noncoding RNAs in the metastasis of oral squamous cell carcinoma

Y Xu, E Jiang, Z Shao, Z Shang - Frontiers in Oncology, 2021 - frontiersin.org
Oral squamous cell carcinoma (OSCC) is a common malignant tumor worldwide. Metastasis
is the main cause of the death of OSCC patients. Long noncoding RNAs (lncRNAs), one of …

Plakoglobin regulates cell motility through Rho-and fibronectin-dependent Src signaling

V Todorović, BV Desai, MJS Patterson… - Journal of cell …, 2010 - journals.biologists.com
We previously showed that the cell–cell junction protein plakoglobin (PG) not only
suppresses motility of keratinocytes in contact with each other, but also, unexpectedly, of …

Bio‐derived hydroxystearic acid ameliorates skin age spots and conspicuous pores

R Schütz, AV Rawlings, E Wandeler… - … Journal of Cosmetic …, 2019 - Wiley Online Library
Introduction We report on the preparation and efficacy of 10‐hydroxystearic acid (HSA) that
improves facial age spots and conspicuous pores. Methods The hydration of oleic acid into …

Human corneal endothelial cells from older donors can be cultured and passaged on cell‐derived extracellular matrix

M Parekh, T Ramos, F O'Sullivan… - Acta …, 2021 - Wiley Online Library
Purpose To investigate the effect of culturing human corneal endothelial cells (HCEnCs)
from older donors on extracellular matrix (ECM) derived from human corneal endothelial cell …

Transient Mitomycin C-treatment of human corneal epithelial cells and fibroblasts alters cell migration, cytokine secretion, and matrix accumulation

S Pal-Ghosh, G Tadvalkar, VR Lieberman, X Guo… - Scientific Reports, 2019 - nature.com
A single application of Mitomycin C (MMC) is used clinically in ophthalmology to reduce
scarring and enhance wound resolution after surgery. Here we show in vitro that a 3-hour …