The potential and challenges of nanopore sequencing

D Branton, DW Deamer, A Marziali, H Bayley… - Nature …, 2008 - nature.com
A nanopore-based device provides single-molecule detection and analytical capabilities
that are achieved by electrophoretically driving molecules in solution through a nano-scale …

Nanopore analytics: sensing of single molecules

S Howorka, Z Siwy - Chemical Society Reviews, 2009 - pubs.rsc.org
In nanopore analytics, individual molecules pass through a single nanopore giving rise to
detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore …

[图书][B] Polymer translocation

M Muthukumar - 2016 - books.google.com
A reflection of the significant advances in the field, this book discusses the macromolecular
basis of polymer translocation that have emerged based on experimentation, new models …

Colloquium: Physical approaches to DNA sequencing and detection

M Zwolak, M Di Ventra - Reviews of Modern Physics, 2008 - APS
With the continued improvement of sequencing technologies, the prospect of genome-based
medicine is now at the forefront of scientific research. To realize this potential, however, a …

Deciphering ionic current signatures of DNA transport through a nanopore

A Aksimentiev - Nanoscale, 2010 - pubs.rsc.org
Within just a decade from the pioneering work demonstrating the utility of nanopores for
molecular sensing, nanopores have emerged as versatile systems for single-molecule …

Single-polymer dynamics under constraints: scaling theory and computer experiment

A Milchev - Journal of Physics: Condensed Matter, 2011 - iopscience.iop.org
The relaxation, diffusion and translocation dynamics of single linear polymer chains in
confinement is briefly reviewed with emphasis on the comparison between theoretical …

Influence of polymer-pore interactions on translocation

K Luo, T Ala-Nissila, SC Ying, A Bhattacharya - Physical Review Letters, 2007 - APS
We investigate the influence of polymer-pore interactions on the translocation dynamics
using Langevin dynamics simulations. An attractive interaction can greatly improve the …

[HTML][HTML] Nanopore sensing: A physical-chemical approach

JWF Robertson, ML Ghimire, JE Reiner - Biochimica et Biophysica Acta …, 2021 - Elsevier
Protein nanopores have emerged as an important class of sensors for the understanding of
biophysical processes, such as molecular transport across membranes, and for the …

DNA sequencing by synthesis using modified nucleotides and nanopore detection

J Ju, S Kumar, Z Li, C Tao, M Chien, JJ Russo… - 2012 - Google Patents
WO2012083249A2 - Dna sequencing by synthesis using modified nucleotides and nanopore
detection - Google Patents WO2012083249A2 - Dna sequencing by synthesis using modified …

Single-nanoparticle detection using a low-aspect-ratio pore

M Tsutsui, S Hongo, Y He, M Taniguchi, N Gemma… - ACS …, 2012 - ACS Publications
We explored single-particle translocation through a low thickness-to-diameter aspect ratio
Si3N4 pore mimicking graphene nanopore structure by a resistive pulse method. Ionic …