With less than one percent of systemically injected nanoparticles accumulating in tumors,
several novel approaches have been spurred to direct and release the therapy in or near …

The objective of this study was to investigate the anticancer activities of biodegradable
polymeric micelles composed of monomethoxy poly (ethylene glycol), polylactic acid, and …

3D cancer cell cultures have enabled new opportunities for replacing compound testing in
experimental animals. However, most solid tumors are composed of multiple cell types …

The role of tumor stroma in solid tumors has been widely recognized in cancer progression,
metastasis and chemoresistance. Cancer-associated fibroblasts (CAFs) play a crucial role in …

This dissertation focuses on the use of nanoparticles as drug delivery systems for cancer
therapy, specifically on their interactions with cells and the tumour microenvironment. It …