Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption

Y Touitou, A Reinberg, D Touitou - Life sciences, 2017 - Elsevier
Abstract Exposure to Artificial Light At Night (ALAN) results in a disruption of the circadian
system, which is deleterious to health. In industrialized countries, 75% of the total workforce …

[HTML][HTML] Melatonin in cancer treatment: current knowledge and future opportunities

WH Talib, AR Alsayed, A Abuawad, S Daoud… - Molecules, 2021 - mdpi.com
Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and
experimental studies have documented that melatonin could inhibit different types of cancer …

[HTML][HTML] Melatonin, a full service anti-cancer agent: inhibition of initiation, progression and metastasis

RJ Reiter, SA Rosales-Corral, DX Tan… - International journal of …, 2017 - mdpi.com
There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …

[HTML][HTML] Melatonin and cancer hallmarks

WH Talib - Molecules, 2018 - mdpi.com
Melatonin is a natural indoleamine produced by the pineal gland that has many functions,
including regulation of the circadian rhythm. Many studies have reported the anticancer …

Melatonin and its ubiquitous anticancer effects

S Bhattacharya, KK Patel, D Dehari, AK Agrawal… - Molecular and cellular …, 2019 - Springer
Abstract Melatonin (N-acetyl-5-methoxy-tryptamine), which is generally considered as
pleiotropic and multitasking molecule, secretes from pineal gland at night under normal light …

[HTML][HTML] Protecting the melatonin rhythm through circadian healthy light exposure

MA Bonmati-Carrion, R Arguelles-Prieto… - International journal of …, 2014 - mdpi.com
Currently, in developed countries, nights are excessively illuminated (light at night), whereas
daytime is mainly spent indoors, and thus people are exposed to much lower light intensities …

Melatonin: a multitasking molecule

RJ Reiter, DX Tan, L Fuentes-Broto - Progress in brain research, 2010 - Elsevier
Abstract Melatonin (N-acetyl-5-methoxytryptamine) has revealed itself as an ubiquitously
distributed and functionally diverse molecule. The mechanisms that control its synthesis …

[HTML][HTML] Melatonin: an inhibitor of breast cancer

SM Hill, VP Belancio, RT Dauchy… - Endocrine-related …, 2015 - erc.bioscientifica.com
The present review discusses recent work on melatonin-mediated circadian regulation, the
metabolic and molecular signaling mechanisms that are involved in human breast cancer …

Anti-inflammatory effects of Melatonin: A mechanistic review

SM Nabavi, SF Nabavi, A Sureda, J Xiao… - Critical reviews in …, 2019 - Taylor & Francis
Abstract N-acetyl-5-methoxy-tryptamine (melatonin) is a natural substance produced both by
plants, as a secondary metabolite, and animals, by the pineal gland and other tissues. In …

Oncostatic activities of melatonin: Roles in cell cycle, apoptosis, and autophagy

N Targhazeh, RJ Reiter, M Rahimi, D Qujeq, T Yousefi… - Biochimie, 2022 - Elsevier
Melatonin, the major secretory product of the pineal gland, not only regulates circadian
rhythms, mood, and sleep but also has actions in neoplastic processes which are being …