Clinical actionability of molecular targets in endometrial cancer
ME Urick, DW Bell - Nature Reviews Cancer, 2019 - nature.com
Abstract Endometrial cancer accounts for~ 76,000 deaths among women each year
worldwide. Disease mortality and the increasing number of new diagnoses make …
worldwide. Disease mortality and the increasing number of new diagnoses make …
The rise of a novel classification system for endometrial carcinoma; integration of molecular subclasses
J McAlpine, A Leon‐Castillo… - The Journal of pathology, 2018 - Wiley Online Library
Endometrial cancer is a clinically heterogeneous disease and it is becoming increasingly
clear that this heterogeneity may be a function of the diversity of the underlying molecular …
clear that this heterogeneity may be a function of the diversity of the underlying molecular …
[HTML][HTML] Molecular features of cancers exhibiting exceptional responses to treatment
A small fraction of cancer patients with advanced disease survive significantly longer than
patients with clinically comparable tumors. Molecular mechanisms for exceptional …
patients with clinically comparable tumors. Molecular mechanisms for exceptional …
Characterization of mismatch‐repair/microsatellite instability‐discordant endometrial cancers
Abstract Background Mismatch‐repair (MMR)/microsatellite instability (MSI) status has
therapeutic implications in endometrial cancer (EC). The authors evaluated the concordance …
therapeutic implications in endometrial cancer (EC). The authors evaluated the concordance …
The proportion of endometrial tumours associated with Lynch syndrome (PETALS): A prospective cross-sectional study
Background Lynch syndrome (LS) predisposes to endometrial cancer (EC), colorectal
cancer, and other cancers through inherited pathogenic variants affecting mismatch-repair …
cancer, and other cancers through inherited pathogenic variants affecting mismatch-repair …
Diagnosis of Lynch syndrome and strategies to distinguish Lynch-related tumors from sporadic MSI/dMMR tumors
J Leclerc, C Vermaut, MP Buisine - Cancers, 2021 - mdpi.com
Simple Summary Microsatellite instability (MSI) is a hallmark of Lynch syndrome (LS)-related
tumors but is not specific, as most of MSI/mismatch repair-deficient (dMMR) tumors are …
tumors but is not specific, as most of MSI/mismatch repair-deficient (dMMR) tumors are …
[HTML][HTML] Clinicopathological significance of deficient DNA mismatch repair and MLH1 promoter methylation in endometrioid endometrial carcinoma
A Pasanen, M Loukovaara, R Bützow - Modern Pathology, 2020 - Elsevier
The pathogenesis of DNA mismatch repair (MMR)-deficient endometrial carcinoma (EC) is
driven by inactivating methylation or less frequently mutation of an MMR gene (MLH1 …
driven by inactivating methylation or less frequently mutation of an MMR gene (MLH1 …
Universal endometrial cancer tumor typing: How much has immunohistochemistry, microsatellite instability, and MLH1 methylation improved the diagnosis of Lynch …
RM Kahn, S Gordhandas, BP Maddy… - Cancer, 2019 - Wiley Online Library
Background Universal tumor testing for defective DNA mismatch repair (MMR) is
recommended for all women diagnosed with endometrial cancer to identify those with …
recommended for all women diagnosed with endometrial cancer to identify those with …
Immunotherapy in endometrial cancer
H Mahdi, A Chelariu-Raicu… - International Journal of …, 2023 - ijgc.bmj.com
The Cancer Genome Atlas (TCGA) endometrial cancer data expanded our knowledge about
the role of different immunotherapeutic approaches based on molecular subtypes. Immune …
the role of different immunotherapeutic approaches based on molecular subtypes. Immune …
Endometrial cancer in young women: prognostic factors and treatment outcomes in women aged≤ 40 years
Objective Endometrial cancer in pre-menopausal patients aged≤ 40 years is rare and
poses both diagnostic and management challenges. The goal of this study was to …
poses both diagnostic and management challenges. The goal of this study was to …