The COP9 signalosome: more than a protease
N Wei, G Serino, XW Deng - Trends in biochemical sciences, 2008 - cell.com
The COP9 signalosome (CSN) is a conserved protein complex that functions in the ubiquitin–
proteasome pathway. After two decades of research, we now know that the CSN is a multi …
proteasome pathway. After two decades of research, we now know that the CSN is a multi …
Cullin-RING ubiquitin ligases: global regulation and activation cycles
DR Bosu, ET Kipreos - Cell division, 2008 - Springer
Cullin-RING ubiquitin ligases (CRLs) comprise the largest known category of ubiquitin
ligases. CRLs regulate an extensive number of dynamic cellular processes, including …
ligases. CRLs regulate an extensive number of dynamic cellular processes, including …
[HTML][HTML] Posttranslational modifications of the master transcriptional regulator NPR1 enable dynamic but tight control of plant immune responses
NPR1, a master regulator of basal and systemic acquired resistance in plants, confers
immunity through a transcriptional cascade, which includes transcription activators (eg …
immunity through a transcriptional cascade, which includes transcription activators (eg …
[HTML][HTML] Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity
Systemic acquired resistance (SAR) is a broad-spectrum plant immune response involving
profound transcriptional changes that are regulated by the coactivator NPR1. Nuclear …
profound transcriptional changes that are regulated by the coactivator NPR1. Nuclear …
Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition
JP Lambert, G Ivosev, AL Couzens, B Larsen… - Nature …, 2013 - nature.com
Characterizing changes in protein-protein interactions associated with sequence variants
(eg, disease-associated mutations or splice forms) or following exposure to drugs, growth …
(eg, disease-associated mutations or splice forms) or following exposure to drugs, growth …
Protein homeostasis and synaptic plasticity
IJ Cajigas, T Will, EM Schuman - The EMBO journal, 2010 - embopress.org
It is clear that de novo protein synthesis has an important function in synaptic transmission
and plasticity. A substantial amount of work has shown that mRNA translation in the …
and plasticity. A substantial amount of work has shown that mRNA translation in the …
RNAi screening implicates a SKN-1–dependent transcriptional response in stress resistance and longevity deriving from translation inhibition
J Wang, S Robida-Stubbs, JMA Tullet, JF Rual… - PLoS …, 2010 - journals.plos.org
Caenorhabditis elegans SKN-1 (ortholog of mammalian Nrf1/2/3) is critical for oxidative
stress resistance and promotes longevity under reduced insulin/IGF-1–like signaling (IIS) …
stress resistance and promotes longevity under reduced insulin/IGF-1–like signaling (IIS) …
Mammalian COP9 signalosome
J Kato, N Yoneda‐Kato - Genes to Cells, 2009 - Wiley Online Library
The COP9 signalosome (CSN) complex is highly conserved from yeast to human. Although
the plant CSN was first identified as a negative regulator of photomorphogenesis, the …
the plant CSN was first identified as a negative regulator of photomorphogenesis, the …
F-box-directed CRL complex assembly and regulation by the CSN and CAND1
The COP9 signalosome (CSN) is thought to maintain the stability of cullin-RING ubiquitin
ligases (CRL) by limiting the autocatalytic destruction of substrate adapters such as F box …
ligases (CRL) by limiting the autocatalytic destruction of substrate adapters such as F box …
Untethering the TIR1 auxin receptor from the SCF complex increases its stability and inhibits auxin response
Plant genomes encode large numbers of F-box proteins (FBPs), the substrate recognition
subunit of SKP1–CULLIN–F-box (SCF) ubiquitin ligases. There are∼ 700 FBPs in …
subunit of SKP1–CULLIN–F-box (SCF) ubiquitin ligases. There are∼ 700 FBPs in …