Modulation of NRF2/KEAP1 signaling in preeclampsia

G Tossetta, S Fantone, F Piani, C Crescimanno… - Cells, 2023 - mdpi.com
Placentation is a key and tightly regulated process that ensures the normal development of
the placenta and fetal growth. Preeclampsia (PE) is a hypertensive pregnancy-related …

[PDF][PDF] The role of Nrf2 in oxidative stress-induced endothelial injuries

B Chen, Y Lu, Y Chen, J Cheng - J Endocrinol, 2015 - scholar.archive.org
Endothelial dysfunction is an important risk factor for cardiovascular disease, and it
represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against …

Thyroid hormone regulated genes in cerebral cortex development

J Bernal - Journal of Endocrinology, 2017 - joe.bioscientifica.com
Endothelial dysfunction is an important risk factor for cardiovascular disease, and it
represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against …

Expression profile of C19MC microRNAs in placental tissue in pregnancy-related complications

I Hromadnikova, K Kotlabova, M Ondrackova… - DNA and cell …, 2015 - liebertpub.com
To demonstrate that pregnancy-related complications are associated with alterations in
placental microRNA expression. Gene expression of 15 C19MC microRNAs (miR-512-5p …

Divergent regulation of decidual oxidative-stress response by NRF2 and KEAP1 in preeclampsia with and without fetal growth restriction

SB Mundal, JJ Rakner, GB Silva, LM Gierman… - International Journal of …, 2022 - mdpi.com
Utero-placental development in pregnancy depends on direct maternal–fetal interaction in
the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental …

Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes

M Nezu, T Souma, L Yu, H Sekine, N Takahashi… - Science …, 2017 - science.org
Placental activation of the renin-angiotensin system (RAS) plays a key role in the
pathogenesis of preeclampsia. Reactive oxygen species (ROS) are thought to affect …

The role of endothelial mechanosensitive genes in atherosclerosis and omics approaches

RD Simmons, S Kumar, H Jo - Archives of biochemistry and biophysics, 2016 - Elsevier
Atherosclerosis is the leading cause of morbidity and mortality in the US, and is a
multifactorial disease that preferentially occurs in regions of the arterial tree exposed to …

The role of nuclear factor erythroid 2–related factor 2 (NRF2) in normal and pathological pregnancy: A systematic review

OAG Tantengco, M de Castro Silva… - American journal of …, 2021 - Wiley Online Library
Objective A homeostatic balance between reactive oxygen species production and the
antioxidant redox system is an important component of normal pregnancy. Nuclear Factor …

Magnesium sulphate can alleviate oxidative stress and reduce inflammatory cytokines in rat placenta of intrahepatic cholestasis of pregnancy model

F Han, L Xu, Y Huang, T Chen, T Zhou… - Archives of Gynecology …, 2018 - Springer
Purpose In our study, we try to investigate whether magnesium sulphate (MgSO 4) could
provide protection against oxidative damage and inflammatory response in rat placenta of …

Modulatory mechanism of polyphenols and Nrf2 signaling pathway in LPS challenged pregnancy disorders

T Hussain, B Tan, G Liu, G Murtaza… - Oxidative Medicine …, 2017 - Wiley Online Library
Early embryonic loss and adverse birth outcomes are the major reproductive disorders that
affect both human and animals. The LPS induces inflammation by interacting with robust …