The application of big data to cardiovascular disease: paths to precision medicine

JA Leopold, BA Maron, J Loscalzo - The Journal of clinical …, 2020 - Am Soc Clin Investig
Advanced phenotyping of cardiovascular diseases has evolved with the application of high-
resolution omics screening to populations enrolled in large-scale observational and clinical …

The pathology of chronic obstructive pulmonary disease: progress in the 20th and 21st centuries

K Berg, JL Wright - Archives of pathology & laboratory …, 2016 - meridian.allenpress.com
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and is the
fourth leading cause of death worldwide. There has been significant progress in the …

Integration of multi-omics datasets enables molecular classification of COPD

CX Li, CE Wheelock, CM Sköld… - European Respiratory …, 2018 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is an umbrella diagnosis caused by a
multitude of underlying mechanisms, and molecular sub-phenotyping is needed to develop …

Genetic advances in chronic obstructive pulmonary disease. Insights from COPDGene

MF Ragland, CJ Benway, SM Lutz… - American journal of …, 2019 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that
is influenced by both genetic and environmental factors. For many years, knowledge of the …

The chronic bronchitis phenotype in chronic obstructive pulmonary disease: features and implications

V Kim, GJ Criner - Current opinion in pulmonary medicine, 2015 - journals.lww.com
The chronic bronchitis phenotype in chronic obstructive pulm... : Current Opinion in Pulmonary
Medicine The chronic bronchitis phenotype in chronic obstructive pulmonary disease: features …

Comparison and development of machine learning tools for the prediction of chronic obstructive pulmonary disease in the Chinese population

X Ma, Y Wu, L Zhang, W Yuan, L Yan, S Fan… - Journal of translational …, 2020 - Springer
Background Chronic obstructive pulmonary disease (COPD) is a major public health
problem and cause of mortality worldwide. However, COPD in the early stage is usually not …

Past, present, and future research on the lung microbiome in inflammatory airway disease

LJ Caverly, YJ Huang, MA Sze - Chest, 2019 - Elsevier
COPD, asthma, and cystic fibrosis (CF) are obstructive lung diseases with distinct
pathophysiologies and clinical phenotypes. In this paper, we highlight recent advances in …

Chronic obstructive pulmonary disease with mild airflow limitation: current knowledge and proposal for future research–a consensus document from six scientific …

A Rossi, B Butorac-Petanjek, M Chilosi… - … journal of chronic …, 2017 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity
worldwide, with high and growing prevalence. Its underdiagnosis and hence under …

[HTML][HTML] COPD phenotypes and machine learning cluster analysis: a systematic review and future research agenda

V Nikolaou, S Massaro, M Fakhimi, L Stergioulas… - Respiratory …, 2020 - Elsevier
Abstract Chronic Obstructive Pulmonary Disease (COPD) is a highly heterogeneous
condition projected to become the third leading cause of death worldwide by 2030. To better …

Interstitial features at chest CT enhance the deleterious effects of emphysema in the COPDGene cohort

SY Ash, R Harmouche, JC Ross, AA Diaz, FN Rahaghi… - Radiology, 2018 - pubs.rsna.org
Purpose To determine if interstitial features at chest CT enhance the effect of emphysema on
clinical disease severity in smokers without clinical pulmonary fibrosis. Materials and …