Tissue-resident immune cells in humans
Tissue-resident immune cells span both myeloid and lymphoid cell lineages, have been
found in multiple human tissues, and play integral roles at all stages of the immune …
found in multiple human tissues, and play integral roles at all stages of the immune …
The multifaceted role of tissue-resident memory T cells
Regionalized immune surveillance relies on the concerted efforts of diverse memory T cell
populations. Of these, tissue-resident memory T (TRM) cells are strategically positioned in …
populations. Of these, tissue-resident memory T (TRM) cells are strategically positioned in …
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain …
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain …
Immunological memory diversity in the human upper airway
SI Ramirez, F Faraji, LB Hills, PG Lopez, B Goodwin… - Nature, 2024 - nature.com
The upper airway is an important site of infection, but immune memory in the human upper
airway is poorly understood, with implications for COVID-19 and many other human …
airway is poorly understood, with implications for COVID-19 and many other human …
[HTML][HTML] Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells
Despite repeated associations between T cell infiltration and outcome, human ovarian
cancer remains poorly responsive to immunotherapy. We report that the hallmarks of tumor …
cancer remains poorly responsive to immunotherapy. We report that the hallmarks of tumor …
CD103 fate mapping reveals that intestinal CD103− tissue-resident memory T cells are the primary responders to secondary infection
HY Fung, M Teryek, AD Lemenze, T Bergsbaken - Science immunology, 2022 - science.org
Tissue-resident memory T (TRM) cells remain poised in the tissue and mediate robust
protection from secondary infection. TRM cells within the intestine and other tissues are …
protection from secondary infection. TRM cells within the intestine and other tissues are …
A single-cell analysis framework allows for characterization of CSF leukocytes and their tissue of origin in multiple sclerosis
P Ostkamp, M Deffner… - Science translational …, 2022 - science.org
Peripheral central nervous system (CNS)–infiltrating lymphocytes are a hallmark of
relapsing-remitting multiple sclerosis. Tissue-resident memory T cells (TRM) not only …
relapsing-remitting multiple sclerosis. Tissue-resident memory T cells (TRM) not only …
MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles
T Kammann, C Cai, T Sekine, E Mouchtaridi… - Science …, 2024 - science.org
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize
microbial riboflavin pathway metabolites presented by evolutionarily conserved MR1 …
microbial riboflavin pathway metabolites presented by evolutionarily conserved MR1 …
Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease
RJ Dart, I Zlatareva, P Vantourout, E Theodoridis… - Science, 2023 - science.org
Murine intraepithelial γδ T cells include distinct tissue-protective cells selected by epithelial
butyrophilin-like (BTNL) heteromers. To determine whether this biology is conserved in …
butyrophilin-like (BTNL) heteromers. To determine whether this biology is conserved in …
Tissue-specific differentiation of CD8+ resident memory T cells
K Yang, A Kallies - Trends in Immunology, 2021 - cell.com
CD8+ tissue-resident memory T (T RM) cells play crucial roles in defense against infections
and cancer and have been implicated in autoimmune diseases such as psoriasis. In mice …
and cancer and have been implicated in autoimmune diseases such as psoriasis. In mice …