Ground rules of the pluripotency gene regulatory network
M Li, JCI Belmonte - Nature Reviews Genetics, 2017 - nature.com
Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be
recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to …
recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to …
Genome editing of human pluripotent stem cells to generate human cellular disease models
K Musunuru - Disease models & mechanisms, 2013 - journals.biologists.com
Disease modeling with human pluripotent stem cells has come into the public spotlight with
the awarding of the Nobel Prize in Physiology or Medicine for 2012 to Drs John Gurdon and …
the awarding of the Nobel Prize in Physiology or Medicine for 2012 to Drs John Gurdon and …
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
Nuclear-architecture defects have been shown to correlate with the manifestation of a
number of human diseases as well as ageing,,,. It is therefore plausible that diseases whose …
number of human diseases as well as ageing,,,. It is therefore plausible that diseases whose …
An alternative pluripotent state confers interspecies chimaeric competency
Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of
embryonic cells. Transitory pluripotent cells can be captured at different time points during …
embryonic cells. Transitory pluripotent cells can be captured at different time points during …
Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones
The utility of genome editing technologies for disease modeling and developing cellular
therapies has been extensively documented, but the impact of these technologies on …
therapies has been extensively documented, but the impact of these technologies on …
Transcription activator-like effector nuclease (TALEN)-mediated gene correction in integration-free β-thalassemia induced pluripotent stem cells
β-Thalassemia (β-Thal) is a group of life-threatening blood disorders caused by either point
mutations or deletions of nucleotides in β-globin gene (HBB). It is estimated that 4.5% of the …
mutations or deletions of nucleotides in β-globin gene (HBB). It is estimated that 4.5% of the …
Deconstructing the pluripotency gene regulatory network
M Li, JC Izpisua Belmonte - Nature cell biology, 2018 - nature.com
Pluripotent stem cells can be isolated from embryos or derived by reprogramming.
Pluripotency is stabilized by an interconnected network of pluripotency genes that …
Pluripotency is stabilized by an interconnected network of pluripotency genes that …
A cut above the rest: targeted genome editing technologies in human pluripotent stem cells
Human pluripotent stem cells (hPSCs) offer unprecedented opportunities to study cellular
differentiation and model human diseases. The ability to precisely modify any genomic …
differentiation and model human diseases. The ability to precisely modify any genomic …
Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs
Fanconi anaemia (FA) is a recessive disorder characterized by genomic instability,
congenital abnormalities, cancer predisposition and bone marrow (BM) failure. However, the …
congenital abnormalities, cancer predisposition and bone marrow (BM) failure. However, the …
Navigating the epigenetic landscape of pluripotent stem cells
Pluripotent stem cells, which include embryonic stem cells and induced pluripotent stem
cells, use a complex network of genetic and epigenetic pathways to maintain a delicate …
cells, use a complex network of genetic and epigenetic pathways to maintain a delicate …