Neurologic impairments are usually irreversible as a result of limited regeneration in the
central nervous system. Therefore, based on the regenerative capacity of stem cells …

The retinal pigment epithelium (RPE) is a partner of the neural retina and is indispensable
for vision. In humans, proliferation and transformation (cell-type switching) of RPE cells after …

Proliferative vitreoretinopathy (PVR) is a blinding disease characterized by the formation of
epiretinal membranes through the wound repair process. Though the mechanisms of PVR …

Despite remarkable advances in vitreoretinal surgery, proliferative vitreoretinopathy (PVR)
remains a common cause of severe visual loss or blindness. One of the critical reasons for …

Purpose To study the role of long non-coding RNA (lncRNA) MALAT1 in transforming growth
factor beta 1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) of retinal pigment …

Exosomes have recently emerged as a pivotal mediator of many physiological and
pathological processes. However, the role of exosomes in proliferative vitreoretinopathy …

Proliferative vitreoretinopathy (PVR) is a complication that develops in 5% to 10% of patients
who undergo surgery to correct a detached retina. The only treatment option for PVR is …

Monocarboxylate transporter (MCT) 4 is a heteromeric proton-coupled lactate transporter
that is noncovalently linked to the extracellular matrix metalloproteinase inducer CD147 and …

Background Epithelial-mesenchymal transition (EMT) of the retinal pigment epithelial (RPE)
cells is a critical step in the pathogenesis of proliferative vitreoretinopathy (PVR). Some …

Proliferative vitreoretinopathy (PVR) exemplifies a disease that is difficult to predict, lacks
effective treatment options, and substantially reduces the quality of life of an individual …