In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent
methyltransferases and SAM are evaluated. Their structural classification and diversity is …

Covering: up to January 2012 The addition of a methyl moiety to a small chemical is a
common transformation in the biosynthesis of natural products across all three domains of …

The distinct activities of organelles depend on the proper function of their membranes.
Coordinated membrane biogenesis of different organelles necessitates lipid transport from …

Methylated lysine and arginine residues in histones represent a crucial part of the histone
code, and recognition of these methylated residues by protein interaction domains …

Internal methylation of eukaryotic mRNAs in the form of N6‐methyladenosine (m6A) and 5‐
methylcytidine (m5C) has long been known to exist, but progress in understanding its role …

RNA methyltransferases (MTases) are ubiquitous enzymes whose hitherto low profile in
medicinal chemistry, contrasts with the surging interest in RNA methylation, the arguably …

Ribosomal RNA undergoes various modifications to optimize ribosomal structure and
expand the topological potential of RNA. The most common nucleotide modifications in …

Benzylisoquinoline alkaloids (BIAs) are a group of specialized metabolites found
predominantly in the plant order Ranunculales. Approximately 2500 naturally occurring BIAs …

Eukaryotic elongation factor 1A (eEF1A) is an essential and highly conserved protein
involved in diverse cellular processes, including translation, cytoskeleton organisation …

The 25S rRNA of yeast contains several base modifications in the functionally important
regions. The enzymes responsible for most of these base modifications remained unknown …