Although gasotransmitters nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide
(H2S) receive a bad connotation; in low concentrations these play a major governing role in …

Background Oxidative stress is the result of cellular troubles related to aerobic metabolism.
Furthermore, this stress is always associated with biological responses evoked by physical …

Ghrelin has proven to be protective against sepsis-induced acute lung injury (ALI) via anti-
inflammatory effects. However, its mechanisms remain poorly understood. Alveolar …

Results: For the established I/R injury model, apelin-13 and SB216763 (GSK-3β inhibitor)
significantly reduced the infarct size (p< 0.05), which could be abolished by LY294002 (PI3K …

Paclitaxel is an effective chemotherapeutic agent, but has some treatment-limiting adverse
effects that markedly decrease patients' quality of life. Peripheral neuropathy is one of these …

Individuals with Down syndrome present many clinical characteristics, such as metabolic,
endocrine, anatomic and neurologic dysfunctions, that contribute to the physiopathology of …

Alzheimer's disease (AD) is a neurodegenerative disorder associated with amyloid-beta
(Aβ) plaque formation and oxidative stress in the brain. Ghrelin has been proven to exert …

Oxidative stress has been recognized as an important mediator in the pathogenesis of age‐
related cataracts; using antioxidant supplements is one plausible strategy to protect the …

Background The male reproductive system is a sensitive and intricate process that can be
distressed following exposure to various toxicants. Therapeutic drugs, especially …

The amino acid, L-Arginine (L-Arg) plays an important role in the cardiovascular system.
Data from the literature show that L-Arg is the only substrate for the production of nitric oxide …