At the frontier of epigenetics of brain sex differences
MM McCarthy, BM Nugent - Frontiers in behavioral neuroscience, 2015 - frontiersin.org
The notion that epigenetics may play an important role in the establishment and
maintenance of sex differences in the brain has garnered great enthusiasm but the reality in …
maintenance of sex differences in the brain has garnered great enthusiasm but the reality in …
The metabolic-epigenetic nexus in type 2 diabetes mellitus
The prevalence of type 2 diabetes mellitus (T2DM) continues to rise globally. Yet the
aetiology and pathophysiology of this noncommunicable, polygenic disease, is poorly …
aetiology and pathophysiology of this noncommunicable, polygenic disease, is poorly …
NSUN2‐mediated m5C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression
S Zuo, L Li, X Wen, X Gu, A Zhuang, R Li… - Clinical and …, 2023 - Wiley Online Library
Background The precise temporal and spatial regulation of N5‐methylcytosine (m5C) RNA
modification plays essential roles in RNA metabolism, and is necessary for the maintenance …
modification plays essential roles in RNA metabolism, and is necessary for the maintenance …
[HTML][HTML] Gene-specific DNA methylation in newborns in response to folic acid supplementation during the second and third trimesters of pregnancy: epigenetic …
Background Emerging evidence suggests that maternal folate status can impact cognitive
development in childhood. Folate-dependent DNA methylation may provide a biological …
development in childhood. Folate-dependent DNA methylation may provide a biological …
Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms
M Ondičová, RE Irwin, SJ Thursby, L Hilman… - Clinical …, 2022 - Springer
Background We previously showed that continued folic acid (FA) supplementation beyond
the first trimester of pregnancy appears to have beneficial effects on neurocognitive …
the first trimester of pregnancy appears to have beneficial effects on neurocognitive …
TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus
N Celarain, J Sánchez-Ruiz de Gordoa, MV Zelaya… - Clinical …, 2016 - Springer
Background Recent genome-wide association studies revealed TREM2 rs75932628-T
variant to be associated with Alzheimer's disease (AD) and other neurodegenerative …
variant to be associated with Alzheimer's disease (AD) and other neurodegenerative …
Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects
Background In recent years, we have come to recognize that a multitude of in utero
exposures have the capacity to induce the development of congenital and metabolic defects …
exposures have the capacity to induce the development of congenital and metabolic defects …
Transcriptome-wide association study of post-trauma symptom trajectories identified GRIN3B as a potential biomarker for PTSD development
Biomarkers that predict symptom trajectories after trauma can facilitate early detection or
intervention for posttraumatic stress disorder (PTSD) and may also advance our …
intervention for posttraumatic stress disorder (PTSD) and may also advance our …
Regulation of miR‐200c and miR‐141 by Methylation in Prostate Cancer
SM Lynch, KM O'Neill, MM McKenna, CP Walsh… - The …, 2016 - Wiley Online Library
BACKGROUND In prostate cancer (PCa), abnormal expression of several microRNAs
(miRNAs) has been previously reported. Increasing evidence shows that aberrant …
(miRNAs) has been previously reported. Increasing evidence shows that aberrant …
A randomized controlled trial of folic acid intervention in pregnancy highlights a putative methylation-regulated control element at ZFP57
Background Maternal blood folate concentrations during pregnancy have been previously
linked with DNA methylation patterns, but this has been done predominantly through …
linked with DNA methylation patterns, but this has been done predominantly through …