Metallodrugs are unique: Opportunities and challenges of discovery and development

EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …

Metallodrugs in cancer nanomedicine

Q Peña, A Wang, O Zaremba, Y Shi… - Chemical society …, 2022 - pubs.rsc.org
Metal complexes are extensively used for cancer therapy. The multiple variables available
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …

Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT

L Feng, C Li, L Liu, Z Wang, Z Chen, J Yu, W Ji… - ACS …, 2022 - ACS Publications
Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy
(PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy …

Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway

SR Li, LL Bu, L Cai - Signal transduction and targeted therapy, 2022 - nature.com
In a recent study published in Science, Tsvetkov et al 1. shed a light on a new form of cell
death, copper-dependent cell death (termed cuproptosis). They defined “cuproptosis” as a …

Toward multi-targeted platinum and ruthenium drugs—a new paradigm in cancer drug treatment regimens?

RG Kenny, CJ Marmion - Chemical reviews, 2019 - ACS Publications
While medicinal inorganic chemistry has been practised for over 5000 years, it was not until
the late 1800s when Alfred Werner published his ground-breaking research on coordination …

Stimuli-responsive therapeutic metallodrugs

X Wang, X Wang, S Jin, N Muhammad, Z Guo - Chemical reviews, 2018 - ACS Publications
The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …

Toxicity of metal compounds: knowledge and myths

KS Egorova, VP Ananikov - Organometallics, 2017 - ACS Publications
Organometallic reagents and metal catalysts are used ubiquitously in academia and
industry. Not surprisingly, the biological activity and environmental danger of metal …

Classification of metal-based drugs according to their mechanisms of action

E Boros, PJ Dyson, G Gasser - Chem, 2020 - cell.com
Metal-based drugs and imaging agents are extensively used in the clinic for the treatment
and diagnosis of cancers and a wide range of other diseases. The current clinical arsenal of …

Chemical design and synthesis of functionalized probes for imaging and treating tumor hypoxia

J Liu, W Bu, J Shi - Chemical reviews, 2017 - ACS Publications
Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

Aggregation-induced emission: together we shine, united we soar!

J Mei, NLC Leung, RTK Kwok, JWY Lam… - Chemical …, 2015 - ACS Publications
Light is of essential importance to the universe and humankind. Light has been, and
continues to be, one of the most fundamental and indispensable elements to life and society …