Designing strategies, structural activity relationship and biological activity of recently developed nitrogen containing heterocyclic compounds as epidermal growth …
Cancer cells have the ability of dysregulation and autonomous proliferation due to
unchecked production of definite molecules. These molecules are involved in the cell growth …
unchecked production of definite molecules. These molecules are involved in the cell growth …
Recent advances in epidermal growth factor receptor inhibitors (EGFRIs) and their role in the treatment of cancer: a review
A Unnisa, AK Chettupalli, T Hussain… - Anti-Cancer Agents in …, 2022 - ingentaconnect.com
Tyrosine kinases are known to play a role in tumour growth and proliferation, and they have
become common drug targets. Tyrosine kinase inhibitors (TKIs) prohibit associated kinases …
become common drug targets. Tyrosine kinase inhibitors (TKIs) prohibit associated kinases …
Synthesis and characterization of novel thiazole derivatives as potential anticancer agents: Molecular docking and DFT studies
New thiazole derivatives (2a-l) were synthesized via the reaction of 2-(3-cyano-4-
isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid with substituted phenyl amines. The …
isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid with substituted phenyl amines. The …
Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors
The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
Experimental and theoretical examinations of triazole linked saccharin derivatives as organic corrosion inhibitors for mild steel in hydrochloric acid
The new triazole linked saccharin derivatives namely, 2-(3-methyl-1H-1, 2, 4-triazol-5-yl)
benzo [d] isothiazol-3 (2H)-one 1, 1-dioxide (MTD) and 2-(3-isopropyl-1H-1, 2, 4-triazol-5-yl) …
benzo [d] isothiazol-3 (2H)-one 1, 1-dioxide (MTD) and 2-(3-isopropyl-1H-1, 2, 4-triazol-5-yl) …
Design, synthesis, anticancer activity and molecular docking of novel 1H-benzo [d] imidazole derivatives as potential EGFR inhibitors
CE Theodore, G Sivaiah, SBB Prasad… - Journal of Molecular …, 2023 - Elsevier
Here, we present the design, synthesis, and evaluation of a new series of 1H-benzo [d]
imidazole derivatives (10a–j) to determine their anticancer efficacy. The MCF-7 and HCT116 …
imidazole derivatives (10a–j) to determine their anticancer efficacy. The MCF-7 and HCT116 …
Synthesis of a novel chloroquinoline, rhodanine encompassed 1, 2, 3-triazole scaffolds and molecular docking evaluation of their cytotoxicity
A novel series of quinoline-linked rhodanine bearing 1, 2, 3-triazole analogs (10a-l) have
been designed and prepared. All the novel hybrids were analyzed and characterized by …
been designed and prepared. All the novel hybrids were analyzed and characterized by …
Design and synthesis of novel benzimidazole linked thiazole derivatives as promising inhibitors of drug-resistant tuberculosis
Despite combination therapy is effective in treating tuberculosis (TB) caused by susceptible
Mycobacterium tuberculosis (Mtb) strains, overcoming multidrug resistance (MDR) remains …
Mycobacterium tuberculosis (Mtb) strains, overcoming multidrug resistance (MDR) remains …
Design, synthesis and molecular docking studies of imidazole and benzimidazole linked ethionamide derivatives as inhibitors of InhA and antituberculosis agents
To explore effective antituberculosis agents, a new class of imidazoles and benzimidazoles
linked ethionamide analogs were designed and synthesized. The elemental analysis, 1 H …
linked ethionamide analogs were designed and synthesized. The elemental analysis, 1 H …
Synthesis, anticancer activity and molecular docking of new pyrazolo [1, 5-a] pyrimidine derivatives as EGFR/HER2 dual kinase inhibitors
G Sivaiah, R Raveesha, SBB Prasad, KY Kumar… - Journal of Molecular …, 2023 - Elsevier
Abstract The pyrazolo [1, 5-a] pyrimidine core framework is a good starting point for the
synthesis of drug-like molecules since the biological activity is determined by the kind and …
synthesis of drug-like molecules since the biological activity is determined by the kind and …