Bile acids and the gut microbiota: metabolic interactions and impacts on disease

SL Collins, JG Stine, JE Bisanz, CD Okafor… - Nature Reviews …, 2023 - nature.com
Despite decades of bile acid research, diverse biological roles for bile acids have been
discovered recently due to developments in understanding the human microbiota. As …

Gut–liver axis: barriers and functional circuits

O Pabst, MW Hornef, FG Schaap, V Cerovic… - Nature Reviews …, 2023 - nature.com
The gut and the liver are characterized by mutual interactions between both organs, the
microbiome, diet and other environmental factors. The sum of these interactions is …

The role of bile acids in carcinogenesis

T Režen, D Rozman, T Kovács, P Kovács… - Cellular and molecular …, 2022 - Springer
Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …

Gut microbiota Turicibacter strains differentially modify bile acids and host lipids

JB Lynch, EL Gonzalez, K Choy, KF Faull… - Nature …, 2023 - nature.com
Bacteria from the Turicibacter genus are prominent members of the mammalian gut
microbiota and correlate with alterations in dietary fat and body weight, but the specific …

Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease

B Jia, Y Zou, X Han, JW Bae, CO Jeon - Trends in Microbiology, 2023 - cell.com
Cardiovascular disease (CVD) is a health problem worldwide, and elevated cholesterol
levels are a key risk factor for the disease. Dysbiotic gut microbiota has been shown to be …

In vitro interaction network of a synthetic gut bacterial community

AS Weiss, AG Burrichter, AC Durai Raj… - The ISME …, 2022 - academic.oup.com
A key challenge in microbiome research is to predict the functionality of microbial
communities based on community membership and (meta)-genomic data. As central …

Molecular basis of bile acid-FXR-FGF15/19 signaling axis

T Katafuchi, M Makishima - International journal of molecular sciences, 2022 - mdpi.com
Bile acids (BAs) are a group of amphiphilic molecules consisting of a rigid steroid core
attached to a hydroxyl group with a varying number, position, and orientation, and a …

Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut

H Ye, S Borusak, C Eberl, J Krasenbrink… - Nature …, 2023 - nature.com
Taurine-respiring gut bacteria produce H2S with ambivalent impact on host health. We
report the isolation and ecophysiological characterization of a taurine-respiring mouse gut …

Bile acids in immunity: Bidirectional mediators between the host and the microbiota

U Godlewska, E Bulanda, TP Wypych - Frontiers in Immunology, 2022 - frontiersin.org
Host-microbiota interactions are bidirectional. On one hand, ecological pressures exerted by
the host shape the composition and function of the microbiota. On the other, resident …

[HTML][HTML] Dysbiosis of gut microbiota is associated with the progression of radiation-induced intestinal injury and is alleviated by oral compound probiotics in mouse …

TS Zhao, LW Xie, S Cai, JY Xu, H Zhou… - Frontiers in cellular …, 2021 - frontiersin.org
The acute radiation-induced intestinal injury (RIII) has raised much concerns and is
influenced by non-cytocidal radiation effects including the perturbations in gut microbiota …