Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …

Cystic Fibrosis (CF) is a disease caused by mutations in the CFTR gene that severely affects
the lungs as well as extra-pulmonary tissues, including the gastrointestinal (GI) tract. CFTR …

Cystic fibrosis (CF) is a monogenetic disease resulting from mutations in the Cystic Fibrosis
Transmembrane conductance Regulator (CFTR) gene encoding an anion channel. Recent …

The airway epithelium is a critical component of the respiratory system, serving as a barrier
against inhaled pathogens and toxins. It is composed of various cell types, each with specific …

The transcriptomic analysis of microarray and RNA-Seq datasets followed our own
bioinformatic pipeline to identify a transcriptional regulatory network of lung cancer. Twenty …

Despite the major advances and successes in finding and establishing new treatments that
tackle the basic defect in Cystic Fibrosis (CF), there is still an unmet need to bring these …

Cystic fibrosis (CF) is an autosomal recessive, life-threatening condition affecting many
organs and tissues, the lung disease being the chief cause of morbidity and mortality …

Single cell RNA-sequencing has accurately identified cell types within the human airway
that express the Cystic Fibrosis Transmembrane Conductance regulator (CFTR) gene. Low …

Cystic fibrosis (CF) cells display a more cancer-like phenotype vs. non-CF cells. KLF4
overexpression has been described in CF and this transcriptional factor acts as a negative …

Background Cardiac hypertrophy (CH) is a well‐established risk factor for many
cardiovascular diseases and a primary cause of mortality and morbidity among older adults …