Even though enzymes are the cornerstones of living systems, it has so far proven difficult to deploy artificial catalysts in a biological setting. Organocatalysts are arguably well-suited …
The two main strategies for enzyme engineering, directed evolution and rational design, have found widespread applications in improving the intrinsic activities of proteins. Although …
Supramolecular self-assembly of fibrous components and liquid–liquid phase separation are at the extremes of the order-to-disorder spectrum. They collectively play key roles in …
There is an increasing interest in synthetic systems that can execute bioinspired chemical reactions without requiring the complex structures that characterize enzymes in their …
Peptides and their conjugates (to lipids, bulky N-terminals, or other groups) can self- assemble into nanostructures such as fibrils, nanotubes, coiled coil bundles, and micelles …
Focusing on applications in separation, adsorption and catalysis, this handbook underlines the importance of this hot and exciting topic. It provides an excellent insight into the …
We describe the design of peptides with properties like thermostability, pH stability, and antibacterial activity against a few bacterial food pathogens. Insights obtained from classical …
BM Bonk, JW Weis, B Tidor - Journal of the American Chemical …, 2019 - ACS Publications
Despite tremendous progress in understanding and engineering enzymes, knowledge of how enzyme structures and their dynamics induce observed catalytic properties is …
Self-assembly of short de novo designed peptides gives rise to catalytic amyloids capable of facilitating multiple chemical transformations. We show that catalytic amyloids can efficiently …