A review of manufacturing capabilities of cell spheroid generation technologies and future development

D Liu, S Chen, M Win Naing - Biotechnology and …, 2021 - Wiley Online Library
Spheroid culture provides cells with a three‐dimensional environment that can better mimic
physiological conditions compared to monolayer culture. Technologies involved in the …

Regulation and directing stem cell fate by tissue engineering functional microenvironments: scaffold physical and chemical cues

F Xing, L Li, C Zhou, C Long, L Wu, H Lei… - Stem cells …, 2019 - Wiley Online Library
It is well known that stem cells reside within tissue engineering functional
microenvironments that physically localize them and direct their stem cell fate. Recent efforts …

Next‐Generation Preclinical Functional Testing Models in Cancer Precision Medicine: CTC‐Derived Organoids

L Huang, Y Xu, N Wang, K Yi, X Xi, H Si… - Small …, 2024 - Wiley Online Library
Basic and clinical cancer research requires tumor models that consistently recapitulate the
characteristics of prima tumors. As ex vivo 3D cultures of patient tumor cells, patient‐derived …

Extracellular vesicles derived from human dental pulp stem cells promote osteogenesis of adipose-derived stem cells via the MAPK pathway

Q Jin, P Li, K Yuan, F Zhao, X Zhu… - Journal of tissue …, 2020 - journals.sagepub.com
Recent studies have shown that co-culture systems play an important role in bone tissue
engineering. In this study, human dental pulp stem cells (hDPSCs) were co-cultured with …

Ex vivo expansion and drug sensitivity profiling of circulating tumor cells from patients with small cell lung cancer

HL Lee, JF Chiou, PY Wang, LS Lu, CN Shen, HL Hsu… - Cancers, 2020 - mdpi.com
Simple Summary Small cell lung cancer (SCLC) is an overly aggressive cancer
characterized by rapid growth, early metastatic spread, and consequently reducing overall …

Modulation of human multipotent and pluripotent stem cells using surface nanotopographies and surface-immobilised bioactive signals: A review

PY Wang, H Thissen, P Kingshott - Acta biomaterialia, 2016 - Elsevier
The ability to control the interactions of stem cells with synthetic surfaces is proving to be
effective and essential for the quality of passaged stem cells and ultimately the success of …

Modulation of human mesenchymal and pluripotent stem cell behavior using biophysical and biochemical cues: A review

S Ding, P Kingshott, H Thissen, M Pera… - Biotechnology and …, 2017 - Wiley Online Library
In vitro manipulation of human stem cells is a critical process in regenerative medicine and
cellular therapies. Strategies and methods to maintain stem cells and direct them into …

Artificial tumor matrices and bioengineered tools for tumoroid generation

YC Liu, P Chen, R Chang, X Liu, JW Jhang… - …, 2024 - iopscience.iop.org
The tumor microenvironment (TME) is critical for tumor growth and metastasis. The TME
contains cancer-associated cells, tumor matrix, and tumor secretory factors. The fabrication …

Binary colloidal crystals (BCCs): Interactions, fabrication, and applications

FS Diba, A Boden, H Thissen, M Bhave… - Advances in Colloid and …, 2018 - Elsevier
The organization of matter into hierarchical structures is a fundamental characteristic of
functional materials and living organisms. Binary colloidal crystal (BCC) systems present a …

Combinatorial approach of binary colloidal crystals and CRISPR activation to improve induced pluripotent stem cell differentiation into neurons

D Urrutia-Cabrera, R Hsiang-Chi Liou… - … Applied Materials & …, 2022 - ACS Publications
Conventional methods of neuronal differentiation in human induced pluripotent stem cells
(iPSCs) are tedious and complicated, involving multistage protocols with complex cocktails …