[HTML][HTML] Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies

A Daiber, S Chlopicki - Free Radical Biology and Medicine, 2020 - Elsevier
According to the latest Global Burden of Disease Study data, non-communicable diseases in
general and cardiovascular disease (CVD) in particular are the leading cause of premature …

The structure and function of the glycocalyx and its connection with blood-brain barrier

J Jin, F Fang, W Gao, H Chen, J Wen… - Frontiers in cellular …, 2021 - frontiersin.org
The vascular endothelial glycocalyx is a dense, bush-like structure that is synthesized and
secreted by endothelial cells and evenly distributed on the surface of vascular endothelial …

[HTML][HTML] Endothelial glycocalyx impairment in disease: focus on hyaluronan shedding

S Dogné, B Flamion - The American journal of pathology, 2020 - Elsevier
Hyaluronan (HA) is a ubiquitous glycosaminoglycan of the extracellular matrix. It is present
in the endothelial glycocalyx covering the apical surface of endothelial cells. The endothelial …

Normothermic perfusion in the assessment and preservation of declined livers before transplantation: hyperoxia and vasoplegia—important lessons from the first 12 …

CJE Watson, V Kosmoliaptsis, LV Randle… - …, 2017 - journals.lww.com
Background A program of normothermic ex situ liver perfusion (NESLiP) was developed to
facilitate better assessment and use of marginal livers, while minimizing cold ischemia …

Regulation and function of endothelial glycocalyx layer in vascular diseases

I Sieve, AK Münster-Kühnel, D Hilfiker-Kleiner - Vascular pharmacology, 2018 - Elsevier
In the vascular system, the endothelial surface layer (ESL) as the inner surface of blood
vessels affects mechanotransduction, vascular permeability, rheology, thrombogenesis, and …

Hypothermic oxygenated perfusion (HOPE) for fatty liver grafts in rats and humans

P Kron, A Schlegel, L Mancina, PA Clavien… - Journal of …, 2018 - Elsevier
Background & Aims Pretreatment of marginal organs by perfusion is a promising opportunity
to make more organs available for transplantation. Protection of human donation after …

[HTML][HTML] Glycocalyx degradation in ischemia-reperfusion injury

Z Abassi, Z Armaly, SN Heyman - The American journal of pathology, 2020 - Elsevier
The glycocalyx is a layer coating the luminal surface of vascular endothelial cells. It is vital
for endothelial function as it participates in microvascular reactivity, endothelium interaction …

Form follows function: the endothelial glycocalyx

A Suzuki, H Tomita, H Okada - Translational Research, 2022 - Elsevier
Three types of capillaries, namely continuous, fenestrated, and sinusoidal, form the
microvascular system; each type has a specialized structure and function to respond to the …

Three-dimensional ultrastructure of capillary endothelial glycocalyx under normal and experimental endotoxemic conditions

H Okada, G Takemura, K Suzuki, K Oda, C Takada… - Critical care, 2017 - Springer
Background Sugar-protein glycocalyx coats healthy endothelium, but its ultrastructure is not
well described. Our aim was to determine the three-dimensional ultrastructure of capillary …

Glycocalyx impairment in vascular disease: focus on inflammation

J Qu, Y Cheng, W Wu, L Yuan, X Liu - Frontiers in Cell and …, 2021 - frontiersin.org
The glycocalyx is a complex polysaccharide-protein layer lining the lumen of vascular
endothelial cells. Changes in the structure and function of the glycocalyx promote an …