Abstract Histone deacetylase (HDAC) 10, a class II family, has been implicated in various
tumors and non-tumor diseases, which makes the discovery of biological functions and …

The understanding of the mechanisms that regulate gene expression to establish
differentiation programs and determine cell lineages, is one of the major challenges in …

Human embryonic stem cells (hESCs) exhibit high levels of proteasome activity, an intrinsic
characteristic required for their self-renewal, pluripotency and differentiation. However, the …

Through intercellular signalling, the somatic compartment of the foetal testis is able to
program primordial germ cells to undergo spermatogenesis. Fibroblast growth factor 9 and …

Epigenetic modifications at the histone level have attracted significant attention because of
their roles in tumorigenesis. Suppressor of variegation 3-9 homolog 2 (SUV39H2, also …

The differentiation of adult stem cells involves extensive chromatin remodeling, mediated in
part by the gene products of histone deacetylase (HDAC) family members. While the …

Redox homeostasis is vital for cellular functions and to prevent the detrimental
consequences of oxidative stress. Pluripotent stem cells (PSCs) have an enhanced …

Pluripotent stem cells possess complex systems that protect them from oxidative stress and
ensure genomic stability, vital for their role in development. Even though it has been …

In the era of 'Big Data'there is a pressing need for tools that provide human interpretable
visualizations of emergent patterns in high-throughput high-dimensional data. Further, to …

The aim of this study was to elucidate the molecular status of single human adult germ stem
cells (haGSCs) and haGSC colonies, which spontaneously developed from the CD49f …