Exploring the JAK/STAT signaling pathway in hepatocellular carcinoma: unraveling signaling complexity and therapeutic implications

H Park, S Lee, J Lee, H Moon, SW Ro - International Journal of Molecular …, 2023 - mdpi.com
Hepatocellular Carcinoma (HCC) continues to pose a substantial global health challenge
due to its high incidence and limited therapeutic options. In recent years, the Janus Kinase …

Calcium homeostasis in the control of mitophagy

M Perrone, S Patergnani, T Di Mambro… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Maintenance of mitochondrial quality is essential for cellular homeostasis.
Among processes responsible for preserving healthy mitochondria, mitophagy selectively …

Flavonoid compounds and their synergistic effects: Promising approaches for the prevention and treatment of psoriasis with emphasis on keratinocytes–A systematic …

A Ebrahimi, M Mehrabi, SS Miraghaee… - International …, 2024 - Elsevier
Psoriasis, a chronic autoimmune skin disorder, causes rapid and excessive skin cell growth
due to immune system dysfunction. Numerous studies have shown that flavonoids have anti …

Proteomimetics of natural regulators of JAK–STAT pathway: novel therapeutic perspectives

S La Manna, I De Benedictis… - Frontiers in molecular …, 2022 - frontiersin.org
The JAK-STAT pathway is a crucial cellular signaling cascade, including an intricate network
of Protein–protein interactions (PPIs) responsible for its regulation. It mediates the activities …

Targeting cytokines in psoriatic arthritis

L Neurath, M Sticherling, G Schett, F Fagni - Cytokine & Growth Factor …, 2024 - Elsevier
Psoriatic arthritis (PsA) is part of the psoriatic disease spectrum and is characterized by a
chronic inflammatory process that affects entheses, tendons and joints. Cytokines produced …

[PDF][PDF] In silico interaction of Berberine with some immunomodulatory targets: A docking analysis

A Ganeshpurkar, A Chaturvedi… - Indian Journal of …, 2022 - op.niscpr.res.in
Plant, mineral, and animal products have been utilized as medications from the beginning of
time to cure a variety of ailments. Use of medicinal herbs to modulate immune function has a …

High-grade synovitis associates with clinical markers and response to therapy in chronic inflammatory arthritis: post hoc analysis of a synovial biomarkers prospective …

C Garaffoni, M Tamussin, I Calciolari, G Lanza… - Frontiers in …, 2024 - frontiersin.org
Background Inflammatory arthritis (IAs), such as rheumatoid arthritis (RA) and psoriatic
arthritis (PsA), are characterized by the presence of chronic synovitis. The Krenn's synovitis …

Recent update on immunopathogenesis of psoriasis

S Chhabra, S Dogra, K Sharma… - Indian Journal of …, 2022 - journals.lww.com
Psoriasis is a chronic disabling complex inflammatory disorder prevalent worldwide with
environmental and genetic components that involve predominantly skin in addition to nails …

Cytokine signatures in psoriatic arthritis patients indicate different phenotypic traits comparing responders and non-responders of IL-17a and TNFα inhibitors

M Skougaard, SB Ditlev, MF Søndergaard… - International Journal of …, 2023 - mdpi.com
This study aimed to explore the dynamic interactions between 32 cytokines and biomarkers
in Psoriatic Arthritis (PsA) patients to compare cytokine signatures of treatment responders …

The role of CCL2/CCR2 axis in cancer and inflammation: The next frontier in nanomedicine

S Pozzi, RS Fainaro - Advanced Drug Delivery Reviews, 2024 - Elsevier
The communication between cells and their microenvironment represents an intrinsic and
essential attribute that takes place in several biological processes, including tissue …