Telomere dysfunction in ageing and age-related diseases
Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …
dysfunction. Telomere shortening and damage are recognized causes of cellular …
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids
RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
R Di Micco, V Krizhanovsky, D Baker… - … reviews Molecular cell …, 2021 - nature.com
Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …
companies that target it to ameliorate a variety of human conditions. Eminently characterized …
Walking a tightrope: the complex balancing act of R-loops in genome stability
JR Brickner, JL Garzon, KA Cimprich - Molecular cell, 2022 - cell.com
Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
U Gioia, S Tavella, P Martínez-Orellana, G Cicio… - Nature Cell …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
The molecular basis and disease relevance of non-homologous DNA end joining
B Zhao, E Rothenberg, DA Ramsden… - … Reviews Molecular Cell …, 2020 - nature.com
Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of any type
of DNA double-strand break (DSB) during most of the cell cycle and is essential for the …
of DNA double-strand break (DSB) during most of the cell cycle and is essential for the …
Regulatory R-loops as facilitators of gene expression and genome stability
C Niehrs, B Luke - Nature reviews Molecular cell biology, 2020 - nature.com
R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …
during transcription. R-loop misregulation is associated with DNA damage, transcription …
The status of the human gene catalogue
Scientists have been trying to identify every gene in the human genome since the initial draft
was published in 2001. In the years since, much progress has been made in identifying …
was published in 2001. In the years since, much progress has been made in identifying …
METTL3 and N6-methyladenosine promote homologous recombination-mediated repair of DSBs by modulating DNA-RNA hybrid accumulation
C Zhang, L Chen, D Peng, A Jiang, Y He, Y Zeng… - Molecular cell, 2020 - cell.com
Double-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired,
may lead to genome instability or cell death. Here, we report that, in response to DSBs, the …
may lead to genome instability or cell death. Here, we report that, in response to DSBs, the …