There is considerable utility in the use of transcranial Doppler ultrasound (TCD) to assess
cerebrovascular function. The brain is unique in its high energy and oxygen demand but …

The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

When the 21st century dawned, there were approximately 600 million persons aged 60 yr
and older worldwide. By the middle of this century, this will more than triple to 2 billion …

Chronic reductions in cerebral blood flow (CBF) and cerebrovascular reactivity to CO 2 are
risk factors for cerebrovascular disease. Higher aerobic fitness is associated with higher …

Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

Cerebrovascular reactivity (CVR), is important for determining future risk of cerebrovascular
disease. It is unclear if primary aging is associated with reductions in CVR because previous …

The population is ageing worldwide, thus increasing the burden of common age-related
disorders to the individual, society and economy. Cerebrovascular diseases (stroke …

Physical activity and exercise have emerged as potential methods to improve brain health
among older adults. However, there are currently no physical activity guidelines aimed at …

Attribution of vascular pathophysiology to reductions in cerebrovascular reactivity (CVR) is
confounded by subjective assessment and the normal variation between anatomic regions …

Exercise is associated with higher cognitive function and is a promising intervention to
reduce the risk of dementia. With advancing age, there are changes in the vasculature that …