Summary Currently, more than 1,200 agrochemicals are listed and many of these are
regularly used by farmers to generate the food supply to support the expanding global …

Inspired by the success of fluorinated corticosteroids in the 1950s and fluoroquinolones in
the 1980s, fluorine-containing pharmaceuticals, which are also known as fluoro …

1. INTRODUCTION “All new is well-forgotten old”, the proverb goes. The current “fluorine
boom” 1 is news only to a novice in the field: the exceptional importance of fluorinated …

The chemistry of heterocyclic compounds has traditionally been and remains a bright area of
chemical science in Russia. This is due to the fact that many heterocycles find the widest …

Direct C2-trifluoromethylation of indole derivatives catalyzed by copper acetate -
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A series of highly active CF 3-containing 3'-(nitroisoxazole) spiro [pyrrolidin-3, 2′-
oxindoles] were synthesized and found to be novel glutathione peroxidase 4 (GPX4)/mouse …

The p53 is a tumor suppressor protein that adjusts cell cycle and growth arrest as well as
genes that restore DNA damage and apoptosis. Murine double minute 2 (MDM2) is a main …

The pyrrolo [2, 1-a] isoquinoline core structure is prevalent in marine natural products and its
fluorinated derivatives are potential medicinal compounds. Herein is described a tungsten …

A mild and concise method for the synthesis of 3-trifluoromethylpyrroles via base-mediated
[3+ 2] cycloaddition of N-acyl α-amino acids and 2-bromo-3, 3, 3-trifluoropropene is …

An easy two-step, one-pot synthesis of halogenated trifluoromethylated pyrroles is realized
by sequential intermolecular hydroamination reaction of 2-trifluoromethyl-1, 3-enynes with …