Cannabidiol: a potential new alternative for the treatment of anxiety, depression, and psychotic disorders

MS García-Gutiérrez, F Navarrete, A Gasparyan… - Biomolecules, 2020 - mdpi.com
The potential therapeutic use of some Cannabis sativa plant compounds has been attracting
great interest, especially for managing neuropsychiatric disorders due to the relative lack of …

THC and CBD: Similarities and differences between siblings

N Stella - Neuron, 2023 - cell.com
Summary Δ 9-tetrahydrocannabinol (THC) and its sibling, cannabidiol (CBD), are produced
by the same Cannabis plant and have similar chemical structures but differ dramatically in …

Cannabis, a cause for anxiety? A critical appraisal of the anxiogenic and anxiolytic properties

L Sharpe, J Sinclair, A Kramer, M de Manincor… - Journal of translational …, 2020 - Springer
Background Cannabis has been documented for use in alleviating anxiety. However, certain
research has also shown that it can produce feelings of anxiety, panic, paranoia and …

Adolescent neurodevelopment and substance use: Receptor expression and behavioral consequences

HHA Thorpe, S Hamidullah, BW Jenkins… - Pharmacology & …, 2020 - Elsevier
Adolescence is the transitional period between childhood and adulthood, during which
extensive brain development occurs. Since this period also overlaps with the initiation of …

Cannabidiol-based natural health products for companion animals: Recent advances in the management of anxiety, pain, and inflammation

HJ Cindy, HPV Rupasinghe - Research in veterinary science, 2021 - Elsevier
Recent advances in cannabidiol (CBD) use in canines and felines for anxiety management,
pain management, and anti-inflammatory effects were reviewed using a literature search …

THC and CBD: villain versus hero? Insights into adolescent exposure

N Pintori, F Caria, MA De Luca, C Miliano - International Journal of …, 2023 - mdpi.com
Cannabis is the most used drug of abuse worldwide. It is well established that the most
abundant phytocannabinoids in this plant are Δ9-tetrahydrocannabinol (THC) and …

Sex-dependent differences in the anxiolytic-like effect of cannabidiol in the elevated plus-maze

D Fabris, MC Carvalho, ML Brandão… - Journal of …, 2022 - journals.sagepub.com
Rationale: Cannabidiol (CBD), the major non-psychoactive constituent of cannabis, has
therapeutic potential for the treatment of anxiety. Most preclinical studies investigate only …

Cannabidiol attenuates fear memory expression in female rats via hippocampal 5-HT1A but not CB1 or CB2 receptors

JM Franzen, I Werle, F Vanz, BB de Oliveira… - …, 2023 - Elsevier
Growing evidence from male rodent and human studies suggests that cannabidiol (CBD)
modulates the expression of aversive memories and anxiety-related responses. The limited …

Sex differences in the neuropsychiatric effects and pharmacokinetics of cannabidiol: A scoping review

J Matheson, Z Bourgault, B Le Foll - Biomolecules, 2022 - mdpi.com
Cannabidiol (CBD) is a non-intoxicating cannabinoid compound with diverse molecular
targets and potential therapeutic effects, including effects relevant to the treatment of …

Orally consumed cannabinoids provide long-lasting relief of allodynia in a mouse model of chronic neuropathic pain

AD Abraham, EJY Leung, BA Wong… - …, 2020 - nature.com
Chronic pain affects a significant percentage of the United States population, and available
pain medications like opioids have drawbacks that make long-term use untenable …