Uncovering post-translational modification-associated protein–protein interactions
In living systems, the chemical space and functional repertoire of proteins are dramatically
expanded through the post-translational modification (PTM) of various amino acid residues …
expanded through the post-translational modification (PTM) of various amino acid residues …
More than a metabolic enzyme: MTHFD2 as a novel target for anticancer therapy?
Z Zhu, GKK Leung - Frontiers in oncology, 2020 - frontiersin.org
The bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a
mitochondrial one-carbon folate metabolic enzyme whose role in cancer was not known …
mitochondrial one-carbon folate metabolic enzyme whose role in cancer was not known …
The bump-and-hole tactic: expanding the scope of chemical genetics
K Islam - Cell chemical biology, 2018 - cell.com
Successful mapping of the human genome has sparked a widespread interest in
deciphering functional information encoded in gene sequences. However, because of the …
deciphering functional information encoded in gene sequences. However, because of the …
MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation
The histone acetyl reader bromodomain-containing protein 4 (BRD4) is an important
regulator of chromatin structure and transcription, yet factors modulating its activity have …
regulator of chromatin structure and transcription, yet factors modulating its activity have …
Genetically encoded crosslinkers to address protein–protein interactions
Noncanonical amino acids (ncAAs) for photo‐and chemical crosslinking are powerful
biochemical tools for studying and manipulating interactions between proteins both in vitro …
biochemical tools for studying and manipulating interactions between proteins both in vitro …
Beyond the marks: reader-effectors as drivers of epigenetics and chromatin engineering
Chromatin is a system of proteins and DNA that regulates chromosome organization and
gene expression in eukaryotes. Essential features that support these processes include …
gene expression in eukaryotes. Essential features that support these processes include …
Photo-cross-linking to delineate epigenetic interactome
Covalent modifications of DNA and histones are key cellular epigenetic marks to regulate
gene functions. Most of these epigenetic marks are added or removed by corresponding …
gene functions. Most of these epigenetic marks are added or removed by corresponding …
Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor …
H Zahid, NM Olson, WCK Pomerantz - Current opinion in chemical biology, 2021 - Elsevier
Nucleosome remodeling provides access to genomic DNA for recruitment of the
transcriptional machinery to mediate gene expression. The aberrant function of nucleosome …
transcriptional machinery to mediate gene expression. The aberrant function of nucleosome …
Mass spectrometry-based protein complex profiling in time and space
Proteins are the building blocks of life and play essential roles in every aspect of biological
processes. Proteins often conduct their functions by forming protein complexes, which are …
processes. Proteins often conduct their functions by forming protein complexes, which are …
Genetic code expansion tools to study lysine acylation
P Neumann‐Staubitz, M Lammers… - Advanced …, 2021 - Wiley Online Library
Lysine acylation is a ubiquitous protein modification that controls various aspects of protein
function, such as the activity, localization, and stability of enzymes. Mass spectrometric …
function, such as the activity, localization, and stability of enzymes. Mass spectrometric …