Ribosome biogenesis factors—from names to functions

K Dörner, C Ruggeri, I Zemp, U Kutay - The EMBO journal, 2023 - embopress.org
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

RNA folding and functions of RNA helicases in ribosome biogenesis

V Mitterer, B Pertschy - RNA biology, 2022 - Taylor & Francis
Eukaryotic ribosome biogenesis involves the synthesis of ribosomal RNA (rRNA) and its
stepwise folding into the unique structure present in mature ribosomes. rRNA folding starts …

Principles of human pre-60S biogenesis

A Vanden Broeck, S Klinge - Science, 2023 - science.org
During the early stages of human large ribosomal subunit (60 S) biogenesis, an ensemble of
assembly factors establishes and fine-tunes the essential RNA functional centers of pre-60 S …

A molecular network of conserved factors keeps ribosomes dormant in the egg

F Leesch, L Lorenzo-Orts, C Pribitzer, I Grishkovskaya… - Nature, 2023 - nature.com
Ribosomes are produced in large quantities during oogenesis and are stored in the egg.
However, the egg and early embryo are translationally repressed,,–. Here, using mass …

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export

X Liang, MQ Zuo, Y Zhang, N Li, C Ma… - Nature …, 2020 - nature.com
Ribosome biogenesis is an elaborate and energetically expensive program that involve two
hundred protein factors in eukaryotes. Nuclear export of pre-ribosomal particles is one …

Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1

M Prattes, I Grishkovskaya, VV Hodirnau… - Nature Structural & …, 2022 - nature.com
Abstract The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that
initiates cytoplasmic maturation of the large ribosomal subunit. Drg1 releases the shuttling …

NOG1 downregulates type I interferon production by targeting phosphorylated interferon regulatory factor 3

Q Xue, Z Zhu, Z Xue, F Yang, W Cao, X Liu, H Liu… - PLoS …, 2023 - journals.plos.org
The innate immune system is the first line of the host's defense, and studying the
mechanisms of the negative regulation of interferon (IFN) signaling is important for …

Transcriptome analysis reveals the molecular mechanisms of the novel Lactobacillus pentosus pentocin against Bacillus cereus

Z Xu, Q Yang, Y Zhu - Food Research International, 2022 - Elsevier
The objective of this study was to investigate the antibacterial effect and mechanism of
Lactobacillus pentosus pentocin against Bacillus cereus. The dynamic growth of B. cereus …

The RNA helicase Dbp10 coordinates assembly factor association with PTC maturation during ribosome biogenesis

V Mitterer, H Hamze, N Kunowska, U Stelzl… - Nucleic Acids …, 2024 - academic.oup.com
During ribosome biogenesis a plethora of assembly factors and essential enzymes drive the
unidirectional maturation of nascent pre-ribosomal subunits. The DEAD-box RNA helicase …

Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles

Y Zhang, X Liang, S Luo, Y Chen, Y Li, C Ma, N Li… - Cell Research, 2023 - nature.com
Eukaryotic ribosome assembly is a highly orchestrated process that involves over two
hundred protein factors. After early assembly events on nascent rRNA in the nucleolus, pre …