Protein cargo in extracellular vesicles as the key mediator in the progression of cancer

K Hánělová, M Raudenská, M Masařík… - Cell Communication and …, 2024 - Springer
Exosomes are small vesicles of endosomal origin that are released by almost all cell types,
even those that are pathologically altered. Exosomes widely participate in cell-to-cell …

Circulating exosome cargoes contain functionally diverse cancer biomarkers: from biogenesis and function to purification and potential translational utility

MI Mitchell, J Ma, CL Carter, O Loudig - Cancers, 2022 - mdpi.com
Simple Summary The indolent nature of some cancers makes early detection challenging,
as such significant effort is placed on identifying circulating cancer biomarkers using …

Heat shock protein A2 is a novel extracellular vesicle-associated protein

DR Sojka, A Abramowicz, M Adamiec-Organiściok… - Scientific Reports, 2023 - nature.com
kDa Heat Shock Proteins (HSPA/HSP70) are chaperones playing a central role in the
proteostasis control mechanisms. Their basal expression can be highly elevated as an …

Emerging Microfluidic Tools for Simultaneous Exosomes and Cargo Biosensing in Liquid Biopsy: New Integrated Miniaturized FFF-Assisted Approach for Colon …

V Marassi, S Giordani, A Placci, A Punzo, C Caliceti… - Sensors, 2023 - mdpi.com
The early-stage diagnosis of cancer is a crucial clinical need. The inadequacies of surgery
tissue biopsy have prompted a transition to a less invasive profiling of molecular biomarkers …

Overexpression of synaptic vesicle protein Rab GTPase 3C promotes vesicular exocytosis and drug resistance in colorectal cancer cells

YC Chang, CH Li, MH Chan, CY Fang… - Molecular …, 2023 - Wiley Online Library
Rab GTPase 3C (RAB3C) is a peripheral membrane protein that is involved in membrane
trafficking (vesicle formation) and cell movement. Recently, researchers have noted the …

The role of exosomal non-coding RNAs in colorectal cancer drug resistance

DI Lampropoulou, E Pliakou, G Aravantinos… - International journal of …, 2022 - mdpi.com
Background: Colorectal cancer (CRC) is one of the most common types of cancer diagnosed
worldwide with high morbidity; drug resistance is often responsible for treatment failure in …

Studies of the Efficacy of Low-Dose Apatinib Monotherapy as Third-Line Treatment in Patients with Metastatic Colorectal Cancer and Apatinib's Novel Anticancer …

L Zhao, Q Yu, C Gao, J Xiang, B Zheng, Y Feng, R Li… - Cancers, 2022 - mdpi.com
Simple Summary We assessed the efficacy and safety of low-dose apatinib monotherapy as
a third-line treatment in patients with metastatic colorectal cancer. The ORR and DCR were …

CRISPR/Cas13-based platforms for a potential next-generation diagnosis of colorectal cancer through exosomes micro-RNA detection: a review

B Durán-Vinet, K Araya-Castro, J Calderón, L Vergara… - Cancers, 2021 - mdpi.com
Simple Summary Colorectal cancer is one of the most prevalent cancers, whereas a
significant number of cases are diagnosed in late cancer stages, and survival rates drop …

Orthogonal Surface‐Enhanced Raman Scattering/Field‐Effect Transistor Detection of Breast and Colorectal Cancer‐Derived Exosomes using Graphene as a Tag …

B Gil, M Keshavarz, D Wales, A Darzi… - Advanced …, 2023 - Wiley Online Library
Cancer is one of the leading causes of high mortality worldwide, affecting most of the body
organs including the breast and colon. Triple‐negative breast (TNBC) and colorectal …

Cell therapy for androgenetic alopecia: elixir or trick?

Y Mao, P Liu, J Wei, Y Xie, Q Zheng, R Li… - Stem Cell Reviews and …, 2023 - Springer
Androgenetic alopecia is the most common cause of hair loss aggravated by increased life
pressure, tension, and anxiety. Although androgenetic alopecia (AGA) does not significantly …