The halogen bond occurs when there is evidence of a net attractive interaction between an
electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic …

Supramolecular chemistry is “the chemistry of the intermolecular bond, covering the
structures and functions of the entities formed by association of two or more chemical …

A halogen bond is a highly directional, electrostatically-driven noncovalent interaction
between a region of positive electrostatic potential on the outer side of the halogen X in a …

The concept of the halogen bond (or X‐bond) has become recognized as contributing
significantly to the specificity in recognition of a large class of halogenated compounds. The …

A significant number of drugs and drug candidates in clinical development are halogenated
structures. For a long time, insertion of halogen atoms on hit or lead compounds was …

In the past several years, halogen bonds have been shown to be relevant in crystal
engineering and biomedical applications. One of the reasons for the utility of these types of …

Although recognized in small molecules for quite some time, the implications of halogen
bonding in biomolecular systems are only now coming to light. In this study, several systems …

Halogen bonding has been extensively described in the context of a variety of self-
assembled supramolecular systems and efficiently utilized in the rational design of materials …

Halogen atoms have been at the center of many rational medicinal chemistry applications in
drug design. While fluorine and chlorine atoms are often added to enhance physicochemical …

Introduction: A large number of drugs and drug candidates in clinical development contain
halogen substituents. For a long time, only the steric and lipophilic contributions of halogens …