Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …

Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

Fibroblasts are non-haematopoietic structural cells that define the architecture of organs,
support the homeostasis of tissue-resident cells and have key roles in fibrosis, cancer …

Diabetic foot ulcers and other chronic wounds with impaired healing can be treated with
bioengineered skin or with growth factors. However, most patients do not benefit from these …

Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …

Chronic wounds are characterized by delayed and dysregulated healing processes. As
such, they have emerged as an increasingly significant threat. The associated morbidity and …

INTRODUCTION Skin wounds generally heal by scarring, a fibrotic process mediated by the
Engrailed-1 (En1) fibroblast lineage. Scars differ from normal unwounded skin in three …

Fibrotic skin disease represents a major global healthcare burden, characterized by
fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts …

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …