Papillomavirus infections—a major cause of human cancers

H Zur Hausen - Biochimica et biophysica acta (BBA)-reviews on cancer, 1996 - Elsevier
The papillomavirus family represents a remarkably heterogeneous group of viruses. At
present, 77 distinct genotypes have been identified in humans and partial sequences have …

The natural history of cervical HPV infection: unresolved issues

CBJ Woodman, SI Collins, LS Young - Nature Reviews Cancer, 2007 - nature.com
The identification of high-risk human papillomavirus (HPV) types as a necessary cause of
cervical cancer offers the prospect of effective primary prevention and the possibility of …

Integration of high‐risk human papillomavirus: a key event in cervical carcinogenesis?

M Pett, N Coleman - The Journal of Pathology: A Journal of the …, 2007 - Wiley Online Library
An important occurrence in cervical carcinogenesis is deregulated expression of the high‐
risk human papillomavirus (HR‐HPV) oncogenes E6 and E7. Several risk factors for cervical …

Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract

N Wentzensen, S Vinokurova, MK Doeberitz - Cancer research, 2004 - AACR
Cancers of the anogenital tract as well as some head and neck cancers are caused by
persistent infections with high-risk type human papillomaviruses (HPVs). Two viral …

Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes

R Klaes, SM Woerner, R Ridder, N Wentzensen… - Cancer research, 1999 - AACR
Cervical cancer emerges from cervical intraepithelial neoplasia (CIN) induced by high-risk
HPV (HR-HPV) infections. However, the vast majority of CIN lesions regresses …

Pathogenesis of human papillomavirus‐associated mucosal disease

IJ Groves, N Coleman - The Journal of pathology, 2015 - Wiley Online Library
Human papillomaviruses (HPVs) are a necessary cause of carcinoma of the cervix and other
mucosal epithelia. Key events in high‐risk HPV (HRHPV)‐associated neoplastic …

Genomic landscape of human papillomavirus–associated cancers

M Rusan, YY Li, PS Hammerman - Clinical cancer research, 2015 - AACR
Recent next-generation sequencing studies have generated a comprehensive overview of
the genomic landscape of human papillomavirus (HPV)–associated cancers. This review …

Is p16-positive oropharyngeal squamous cell carcinoma associated with favorable prognosis? A systematic review and meta-analysis

PP Sedghizadeh, WD Billington, D Paxton, R Ebeed… - Oral oncology, 2016 - Elsevier
The purpose of this systematic review and meta-analysis was to compare the prognosis of
patients with p16 expressing oropharyngeal squamous cell cancers to patients with p16 non …

Molecular mechanisms of HPV mediated neoplastic progression

R Senapati, NN Senapati, B Dwibedi - Infectious Agents and Cancer, 2016 - Springer
Human Papillomavirus is the major etiological agent in the development of cervical cancer
but not a sufficient cause. Despite significant research, the underlying mechanisms of …

Conserved methylation patterns of human papillomavirus type 16 DNA in asymptomatic infection and cervical neoplasia

M Kalantari, IE Calleja-Macias, D Tewari… - Journal of …, 2004 - Am Soc Microbiol
ABSTRACT DNA methylation contributes to the chromatin conformation that represses
transcription of human papillomavirus type16 (HPV-16), which is prevalent in the etiology of …