Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of
endothelial cells lining brain blood vessels. The presence of these protein complexes in the …

Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …

Prevalence, symptoms, and treatment of depression suggest that major depressive
disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is …

Endothelial tight junctions (TJs) regulate the transport of water, ions, and molecules through
the paracellular pathway, serving as an important barrier in blood vessels and maintaining …

The blood-brain barrier (BBB) is a dynamic interface between the peripheral blood supply
and the cerebral parenchyma, controlling the transport of material to and from the brain …

Major psychiatric disorders affect 25% of the population. While genetic and environmental
risk factors have been identified, the underlying pathophysiology of conditions, such as …

Structural and functional integrity of the cerebral vasculature ensures proper brain
development and function, as well as healthy aging. The inability of the brain to store energy …

Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a
dopamine neuron-rich region associated with schizophrenia symptoms. In fact, half of …

Background The etiology in bipolar disorder has not been fully understanding. There are
limited data regarding the relationship between the permeability of intestinal and blood …

In some organs, such as the brain, endothelial cells form a robust and highly selective blood-
to-tissue barrier. However, in other organs, such as the intestine, endothelial cells provide …