Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …

Abstract Systems-based based approaches have begun to shed light on extrinsic factors that
contribute to immune system variation. Among these, CMV (HHV-5, a β-herpesvirus) …

Natural killer T (NKT) cells combine features of the innate and adaptive immune systems.
Recently, it has become evident that these T cells have crucial roles in the response to …

Infection with influenza A virus (IAV) presents a substantial threat to public health worldwide,
with young, elderly, and immunodeficient individuals being particularly susceptible …

The classic concept of self–non-self discrimination by the immune system focused on the
recognition of fragments from proteins presented by classical MHC molecules. However, the …

Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) have co-evolved with humans for
thousands of years and are present at a high prevalence in the population worldwide. HSV …

Epstein-Barr virus (EBV) infects most people and establishes life-long infection controlled by
the host's immune system. The genetic stability of the virus, deep understanding of the viral …

B cells perform many immunological functions, including presenting lipid antigen to CD1d-
restricted invariant natural killer T (iNKT) cells, known to contribute to maintaining tolerance …

The discovery of molecules capable of presenting lipid antigens, the CD1 family, and of the
T cells that recognize them, has opened a new dimensionin our understanding of cell …

CD1-and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic
antigens, such as lipids and small metabolites, and account for a major fraction of circulating …