Activin A in mammalian physiology

E Bloise, P Ciarmela, C Dela Cruz… - Physiological …, 2019 - journals.physiology.org
Activins are dimeric glycoproteins belonging to the transforming growth factor beta
superfamily and resulting from the assembly of two beta subunits, which may also be …

Stem cells differentiation into insulin-producing cells (IPCs): recent advances and current challenges

IBB Silva, CH Kimura, VP Colantoni… - Stem cell research & …, 2022 - Springer
Type 1 diabetes mellitus (T1D) is a chronic disease characterized by an autoimmune
destruction of insulin-producing β-pancreatic cells. Although many advances have been …

Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva

KL Wentworth, U Masharani… - British Journal of Clinical …, 2019 - Wiley Online Library
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease in which heterotopic
bone forms in muscle and soft tissue, leading to joint dysfunction and significant disability …

Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway

Z Zhang, J Wang, Y Chen, L Suo, H Chen… - Cell Communication and …, 2019 - Springer
Background Endometriosis, characterized by the presence of functional endometrial tissues
outside the uterus, is one of the most common gynecological disorders. Endometrial …

Mesenchymal stem cell-derived exosomes protect muscle loss by miR-145-5p activity targeting activin A receptors

KA Cho, DW Choi, YH Kim, J Kim, KH Ryu, SY Woo - Cells, 2021 - mdpi.com
Skeletal muscle mass is decreased under a wide range of pathologic conditions. In
particular, chemotherapy is well known for inducing muscle loss and atrophy. Previous …

Recent progress in drug development for fibrodysplasia ossificans progressiva

X Meng, H Wang, J Hao - Molecular and Cellular Biochemistry, 2022 - Springer
Abstract Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disease caused by
heterozygous missense mutations in Activin A receptor type I which is also known as Activin …

Activin and TGF-β effects on brain development and neural stem cells

G Rodriguez-Martinez, I Velasco - CNS & Neurological …, 2012 - ingentaconnect.com
Transforming Growth Factor-β (TGF-β) family members are ubiquitously expressed,
participating in the regulation of many processes in different cell types both in embryonic …

Activin A secreted by human mesenchymal stem cells induces neuronal development and neurite outgrowth in an in vitro model of Alzheimer's disease: neurogenesis …

SE Park, J Lee, EH Chang, JH Kim, JH Sung… - Archives of pharmacal …, 2016 - Springer
Alzheimer's disease (AD) is characterized by progressive loss of memory in addition to
cortical atrophy. Cortical atrophy in AD brains begins in the parietal and temporal lobes …

Activin signaling in the pathogenesis and therapy of neuropsychiatric diseases

AS Link, F Zheng, C Alzheimer - Frontiers in Molecular Neuroscience, 2016 - frontiersin.org
Activins are members of the transforming growth factor β (TGFβ) family and serve as
multifunctional regulatory proteins in many tissues and organs. In the brain, activin A, which …

Use of early biomarkers in neonatal brain damage and sepsis: state of the art and future perspectives

I Bersani, C Auriti, MP Ronchetti… - BioMed research …, 2015 - Wiley Online Library
The identification of early noninvasive biochemical markers of disease is a crucial issue of
the current scientific research, particularly during the first period of life, since it could provide …