Diabetes mellitus is a chronic heterogeneous metabolic disorder with complex
pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which …

The convergence of advances in medical science, human biology, data science, and
technology has enabled the generation of new insights into the phenotype known as …

A substantial proportion of patients with adult-onset diabetes share features of both type 1
diabetes (T1D) and type 2 diabetes (T2D). These individuals, at diagnosis, clinically …

Recent epidemiological data have shown that more than half of all new cases of type 1
diabetes occur in adults. Key genetic, immune, and metabolic differences exist between …

Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …

Type 1 diabetes is characterized by an immune-mediated depletion of b-cells that results in
lifelong dependence on exogenous insulin. While both type 1 and type 2 diabetes result in …

Advances in molecular methods and the ability to share large population-based datasets are
uncovering heterogeneity within diabetes types, and some commonalities between types …

Diabetes is a much more heterogeneous disease than the present subdivision into types 1
and 2 assumes; type 1 and type 2 diabetes probably represent extremes on a range of …

Adult-onset autoimmune diabetes is a heterogeneous disease that is characterized by a
reduced genetic load, a less intensive autoimmune process and a mild metabolic …

Obesity is a chronic disease that has already reached pandemic proportions and is
becoming one of the leading causes of death and disability worldwide. A comprehensive …