The immune system is a fascinating world of cells, soluble factors, interacting cells, and
tissues, all of which are interconnected. The highly complex nature of the immune system …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

CD4+ T helper (Th) cells play a central role in the adaptive immune response by providing
help to B cells and cytotoxic T cells and by releasing different types of cytokines in tissues to …

CD4+ Th cells play an important role in the development of rheumatoid arthritis (RA) by
regulating adaptive immune response. As major subsets of CD4+ Th cells, Th17 cells can …

Abstract T helper 17 (Th17) cells are important mediators of immune responses against
extracellular bacteria and fungi, and as such play critical regulatory roles in maintaining …

Activation of T cells is dependent on the organized and timely opening and closing of
chromatin. Herein, we identify AP-1 as the transcription factor that directs most of this …

Upon activation, naïve CD4+ T helper (Th) cells differentiate into distinct Th effector cell
lineages depending on the local cytokine environment. However, these polarized Th cells …

Th17 cells are an important therapeutic target in autoimmunity. However, it is known that
Th17 cells exhibit considerable plasticity, particularly at sites of autoimmune inflammation …

Epigenetic modifications affect the differentiation of T cell subsets and the pathogenesis of
autoimmune diseases, but many mechanisms of epigenetic regulation of T cell …