SUMMARY Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …

Alphaherpesviruses (α-HV) are a large family of double-stranded DNA viruses which cause
many human and animal diseases. There are three human α-HVs: Herpes Simplex Viruses …

Herpes simplex virus type 1 (HSV-1) infection triggers a rapid induction of host innate
immune responses. The type I interferon (IFN) signal pathway is a central aspect of host …

Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that primarily infects
epithelial cells of the orofacial mucosa. After initial lytic replication, HSV-1 enters sensory …

The cyclic guanosine monophosphate–adenosine monophosphate (GMP‐AMP) synthase‐
Stimulator of Interferon Genes (cGAS‐STING) pathway is a critical innate immune …

Innate immune responses can impact different stages of viral life cycles. Herpes simplex
virus latent infection of neurons and subsequent reactivation provide a unique context for …

Interferon (IFN) responses are critical for controlling herpes simplex virus 1 (HSV-1). The
importance of neuronal IFN signaling in controlling acute and latent HSV-1 infection remains …

Multiple sclerosis (MS) is characterized by peripheral and central inflammatory features, as
well as demyelination and neurodegeneration. The available Food and Drug Administration …

How type I and II interferons prevent periodic reemergence of latent pathogens in tissues of
diverse cell types remains unknown. Using homogeneous neuron cultures latently infected …

Background Herpes simplex virus type 1 (HSV-1) cause not only mild symptoms but also
blindness and encephalitis. It was previously shown that the immune response against HSV …