Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2019–2020

DJ Harvey - Mass Spectrometry Reviews, 2023 - Wiley Online Library
This review is the tenth update of the original article published in 1999 on the application of
matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of …

Discovery and development of tyrosine-click (Y-click) reaction for the site-selective labelling of proteins

J Chatterjee, A Bandyopadhyay… - Chemical …, 2024 - pubs.rsc.org
With the versatile utility of bio-conjugated peptides and proteins in the fields of agriculture,
food, cosmetics and pharmaceutical industry, the design of smart protocols to conjugate and …

New 1, 2, 3-triazole-containing hybrids as antitumor candidates: Design, click reaction synthesis, DFT calculations, and molecular docking study

IH El Azab, HS El-Sheshtawy, RB Bakr, NAA Elkanzi - Molecules, 2021 - mdpi.com
In an effort to improve and achieve biologically active anticancer agents, a novel series of 1,
2, 3-triazole-containing hybrids were designed and efficiently synthesized via the Cu …

Recent advances in lipopolysaccharide-based glycoconjugate vaccines

H Zhu, CS Rollier, AJ Pollard - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction The public health burden caused by pathogenic Gram-negative bacteria is
increasingly prominent due to antimicrobial resistance. The surface carbohydrates are …

[HTML][HTML] A robust post-insertion method for the preparation of targeted siRNA LNPs

LE Swart, CA Koekman, CW Seinen, H Issa… - International journal of …, 2022 - Elsevier
Targeted delivery of nucleic acids is gaining momentum due to improved efficacy, selectivity,
increased circulation time and enhanced tissue retention in target cells. Using nucleic acid …

[HTML][HTML] Nanoparticles as Delivery Systems for Antigenic Saccharides: From Conjugation Chemistry to Vaccine Design

MJ Archambault, LM Tshibwabwa, M Côté-Cyr… - Vaccines, 2024 - mdpi.com
Glycoconjugate vaccines have been effective in preventing numerous bacterial infectious
diseases and have shown recent potential to treat cancers through active immunotherapy …

Cross reacting material (CRM197) as a carrier protein for carbohydrate conjugate vaccines targeted at bacterial and fungal pathogens

EA Khatuntseva, NE Nifantiev - International Journal of Biological …, 2022 - Elsevier
This paper gives an overview of conjugate glycovaccines which contain recombinant
diphtheria toxoid CRM197 as a carrier protein. A special focus is given to synthetic methods …

Novel simple conjugation chemistries for decoration of GMMA with heterologous antigens

R Di Benedetto, R Alfini, M Carducci, MG Aruta… - International Journal of …, 2021 - mdpi.com
Outer Membrane Vesicles (OMV) constitute a promising platform for the development of
efficient vaccines. OMV can be decorated with heterologous antigens (proteins or …

Conjugation of antibody with temperature-responsive polymer via in situ click reaction to enable biomarker enrichment for increased diagnostic sensitivity

K Hironaka, E Yoshihara, A Nabil, JJ Lai… - Biomaterials …, 2021 - pubs.rsc.org
Early diagnosis of infectious diseases is one of the current prevalent challenges, especially
in low and limited resource settings where simple, fast, portable, cheap, and sensitive …

Conjugation Methods in Synthetic Glycoconjugate Vaccines

Z Huang, S Chen, X Li, H Liu - Chemistry‐Methods, 2024 - Wiley Online Library
In the past two to three decades, synthetic glycoconjugate vaccines have shown great
potential in the prevention of severe infections and protection of high‐risk populations …