A cross‐kingdom view on the immunomodulatory role of MIF/D‐DT proteins in mammalian and plant Pseudomonas infections

R Panstruga, SC Donnelly, J Bernhagen - Immunology, 2022 - Wiley Online Library
Gram‐negative Pseudomonas bacteria are largely harmless saprotrophs, but some species
can be potent pathogens of both plants and mammals. Macrophage migration‐inhibitory …

Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells

L Spiller, R Manjula, F Leissing, J Basquin… - Science …, 2023 - science.org
Mammalian macrophage migration inhibitory factor (MIF) and its paralog, D-dopachrome
tautomerase, are multifunctional inflammatory cytokines. Plants have orthologous MIF and D …

CXCR4 promotes B cell viability by the cooperation of nuclear factor (erythroid-derived 2)-like 2 and hypoxia-inducible factor-1α under hypoxic conditions

JW Jang, PX Thuy, JW Lee, EY Moon - Cell Death & Disease, 2021 - nature.com
B cells that interact with T cells play a role in regulating the defense function by producing
antibodies and inflammatory cytokines. CXC chemokine receptor type 4 (CXCR4) is a …

Betaine modulating MIF-mediated oxidative stress, inflammation and fibrogenesis in thioacetamide-induced nephrotoxicity

B Jorgačević, S Stanković, J Filipović… - Current Medicinal …, 2022 - ingentaconnect.com
Background: Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with
chemokine properties released by various immune and non-immune cells. It contributes to …

Chemokine-like MDL proteins modulate flowering time and innate immunity in plants

K Gruner, F Leissing, D Sinitski, H Thieron… - Journal of Biological …, 2021 - ASBMB
Human macrophage migration inhibitory factor (MIF) is an atypical chemokine implicated in
intercellular signaling and innate immunity. MIF orthologs (MIF/D-DT-like proteins, MDLs) …

Macrophage migration inhibitory factor in Nodding syndrome

G Benedek, M Abed El Latif, K Miller… - PLoS Neglected …, 2021 - journals.plos.org
Nodding syndrome (NS) is a catastrophic and enigmatic childhood epilepsy, accompanied
by multiple neurological impairments and neuroinflammation. Of all the infectious …

Crystal structure of N-terminally hexahistidine-tagged Onchocerca volvulus macrophage migration inhibitory factor-1

AD Kimble, OCO Dawson, L Liu… - Structural Biology and …, 2024 - journals.iucr.org
Onchocerca volvulus causes blindness, onchocerciasis, skin infections and devastating
neurological diseases such as nodding syndrome. New treatments are needed because the …

Characterization of Plasmodium falciparum macrophage migration inhibitory factor homologue and its cysteine deficient mutants

S Schipper, E Springer, J Hahn, S Rahlfs… - Parasitology …, 2022 - Elsevier
Plasmodium falciparum macrophage migration inhibitory factor (PfMIF) is a homologue of
the multifunctional human host cytokine MIF (HsMIF). Upon schizont rupture it is released …

Structures of Arabidopsis thaliana MDL Proteins and Synergistic Effects with the Cytokine MIF on Human Receptors

L Spiller, R Manjula, F Leissing, J Basquin, P Bourilhon… - bioRxiv, 2023 - biorxiv.org
Vertebrates have developed effective immune mechanisms to fight microbial attacks, relying
on a sophisticated network of innate and adaptive responses, a circulatory system, and …

Structures of A. thaliana MDL proteins and synergistic effects with the cytokine MIF on human receptors

LD Spiller - 2024 - oparu.uni-ulm.de
Vertebrates have developed effective immune mechanisms to fight microbial attacks, relying
on a sophisticated network of innate and adaptive responses, a circulatory system, and …